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Vitamin B12 deficiency, infertility & recurrent fetal loss

Catherine McDiarmid-Watt | Tuesday, August 12, 2008 | 0 comments

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Vitamin B12 deficiency, infertility & recurrent fetal lossOBJECTIVE: To examine the relationship of infertility to recurrent fetal loss in patients who were vitamin B12 deficient.

STUDY DESIGN: The obstetric histories of 14 patients presenting with 15 episodes of vitamin B12 deficiency were analyzed. Infertility (two to eight years) had been present in four episodes, and recurrent fetal loss was a feature in 11.

RESULTS: In six episodes, periods of recurrent fetal loss were followed by periods of infertility greater than one year.

CONCLUSION: Hypercoagulability due to raised homocysteine levels may lead to fetal loss when vitamin B12 deficiency first develops. A more prolonged deficiency results in infertility by causing changes in ovulation or development of the ovum or changes leading to defective implantation.

PMID: 11304860 [PubMed - indexed for MEDLINE]


Source: http://www.ncbi.nlm.nih.gov/pubmed/11304860

Related Articles
• Clinical B12 deficiency in one case of recurrent spontaneous pregnancy loss.
[Clin Chem Lab Med. 2003]
• Low Vitamin B(12) level as a risk factor for very early recurrent abortion.
[Eur J Obstet Gynecol Reprod Biol. 2002]



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Catherine

About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

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