Amazon.com lists over 11,000 items under the search term "fertility"

Single hormone shot can replace daily doses in IVF

Catherine McDiarmid-Watt | Sunday, July 29, 2012 | 0 comments

Syringe and drug bottle. Stock Photo credit: BubbelsWomen preparing for fertility treatment get a series of daily, sometimes uncomfortable, hormone shots to kick their ovaries into overdrive, but a European review of previous studies suggests that one long-acting shot may work just as well.

In an analysis of four past studies including over 2,300 women with infertility, researchers found the women were just as likely to get pregnant - and didn't have any more complications - when they got a single, long-acting dose of follicle-stimulating hormone (FSH).

For in vitro fertilization, extra FSH is used to trigger the ovaries to grow and release multiple eggs, which are then fertilized outside the body and transferred to the uterus.

"Long-acting FSH (weekly injection) is a good and safe alternative to daily injections in the first week of ovarian stimulation for IVF," said Jan Kremer from Radboud University Nijmegen Medical Center in the Netherlands, who worked on the study.

The long-acting shot is used in Europe but not currently available in the United States, because it hasn't been approved by the Food and Drug Administration.

The findings, published in The Cochrane Library, cover 2,335 women.

Of that number, 987 got daily FSH shots for a week and 1,348 had one long-acting shot at a range of doses, along with the usual course of other IVF hormone injections.

In studies that used the lowest dose of the long-acting hormone, between 60 and 120 micrograms - fewer women in the one-shot group got pregnant than in the daily FSH comparison group.

However, at slightly higher doses - 150 to 180 micrograms - pregnancy and birth rates didn't suffer: 343 of every 1,000 women getting one long-acting shot had a baby, compared to 336 out of 1,000 in the daily-shot group.

The long-acting shot didn't seem to come with a higher risk of miscarriage, having twins or developing a pregnancy-related complication, including swollen ovaries.

The main advantage of the single shot is convenience, said Samuel Pang, medical director at the Reproductive Science Center of New England in Lexington, Massachusetts.

FSH shots are simple injections that women can give themselves, similar to insulin, but the process can still be difficult for some.

"In my mind, based on the studies that have been done and based on my own experience, it is a safe and effective product," said Pang, who wasn't involved in the new study, to Reuters Health.

"The only caveat is it really needs to be used in well-selected patients."

Like Kremer, he cautioned against using the long-acting shot in women who are unlikely to respond to the hormone, or those who may over-respond.

A week after getting the long-acting shot, many women still need a few daily injections of FSH before they're ready to have their eggs harvested, he added.

Pang worked on research that has been submitted to the FDA on the hormone shot, but says it's at least a year or two away from being available in the United States.

Stock Photo credit: Bubbels
All rights reserved


pin it


TODAY'S BOOK SUGGESTION:
Fathers of a Certain Age: The Joys and Problems of Middle-Aged Fatherhood, by Martin Carnoy. Publisher: Fairview Press; 1st pbk. ed edition (May 6, 1997)Fathers of a Certain Age: The Joys and Problems of Middle-Aged Fatherhood
by Martin Carnoy

-- A father and son interview dozens of men in their 40s and 50s to discover why these men have decided to delay parenting or start over, and how they feel about fathering children in late middle age.

The result is a timely assessment of the challenges and rewards older fathers face, as seen through their own eyes and those of their wives and children.

Men are becoming fathers at 40, 50 or more, but there is very little information on what issues they will have to deal with or how to cope with the new life phase.


Lots of anecdotes of from families with either delayed or remarried fatherhood.


It offers glimpses of societal changes as we are all living longer and healthier and as a result, may have children later. 


Discusses stepkids, May-December marriages, adoption, fathers-at-home, and more.


Paperback: 192 pages - Click to order/for more info:
Fathers of a Certain Age


Hardcover: 181 pages - Click to order/for more info:
Fathers of a Certain Age



Follow us on Twitter, join the conversation on our Facebook page, circle us on Google+, follow our pins on Pinterest.

More Frugal Blogs and Websites:
Born to Love: All your cloth diapering needs, and much more - naturally! We are strong advocates of the personal, social and environmental benefits of natural parenting.
Frugal Freebies: Keep up with the latest free stuff, deals, coupons, and other ways to save money!
My Frugal Baby Tips: Taking care of baby and mom needs naturally, does not have to cost a whole lot of money!

More "Pregnancy Over 40" blogs to visit:
Life Begins... - Pregnancy stories of loss, hope and help
Pregnancy Stories by Age - Daily blog of hope and inspiration!
You Can Get Pregnant in Your 40's - Sharing articles, discussing options and suggestions
Stories of Pregnancy and Birth over 44 - sharing news stories I find online, for inspiration!





Category: , , , ,

Catherine

About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

Find Catherine on Google+ - Circle us on Google+ - Join us on Facebook - Follow us on Twitter

0 comments

WE LOVE COMMENTS!
Don't just sit there, reading this story or article - say something! Do you believe it? Do you think it is impossible? Do you wish it was you? Do you have a story to share (it might get published!)

NOTE: Comments are moderated - just to stop the spambots - and so may take up to a few hours to be approved.

Catherine reserves the right to review, edit, refuse or delete any comment.

Popular Posts