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Short Follicular Phase in Older Women

Catherine McDiarmid-Watt | Sunday, February 04, 2018 | 0 comments

Image: Mother and son, by  tung256 on PixabayIs the Short Follicular Phase in Older Women Secondary to Advanced or Accelerated Dominant Follicle Development?

This study sought to determine whether the shortened follicular phase in ovulatory older women is secondary to advanced (i.e. earlier) or accelerated (i.e. more rapid) folliculogenesis.

Normal ovulatory women, aged 40–45 yr (n = 15) and 20–25 yr (n = 13), underwent daily venipuncture and transvaginal ultrasonography throughout the follicular phase of a spontaneous menstrual cycle (control cycle) and after pituitary down-regulation with a GnRH agonist(study cycle).

As expected, the older subjects in the control cycles demonstrated an elevated day 3 FSH and a shortened follicular phase compared with the younger subjects.

After release from hypothalamic-pituitary-ovarian axis suppression, the early follicular phase FSH peak occurred earlier (6.8 vs. 9.8 d; P greater than 0.01) and was of a greater magnitude (12.1 vs. 6.5 mIU/ml; P greater than 0.01) in the older subjects.

The time from release of suppression until the subsequent LH surge was also shorter (17.5 vs. 20.8 d; P greater than 0.01) in the older group. However, the time from FSH peak to LH surge was similar in the older and younger groups (10.7 vs. 11.0 d; P = 0.74).

Compared with younger women, older subjects had normal follicular phase levels of estradiol and inhibin A and lower levels of inhibin B in both control and study cycles.

We conclude that the shortened follicular phase observed in older ovulatory women is due to earlier dominant follicle selection, independent of hormonal influences from the preceding luteal phase.

Full article: Is the Short Follicular Phase in Older Women Secondary to Advanced or Accelerated Dominant Follicle Development?

Image: Ready: Why Women Are Embracing The New Later Motherhood, by Elizabeth Gregory. Publisher: Basic Books (December 25, 2007)
Ready: Why Women Are Embracing The New Later Motherhood
by Elizabeth Gregory

-- Over the past three decades, skyrocketing numbers of women have chosen to start their families in their late thirties and early forties.

In 2005, ten times as many women had their first child between the ages of 35 and 39 as in 1975, and thirteen times as many had their first between 40 and 44.

Women now have the option to define for themselves when they're ready for family, rather than sticking to a schedule set by social convention.

As a society, however, we have yet to come to terms with the phenomenon of later motherhood, and women who decide it makes sense for them to delay pregnancy often find themselves confronted with alarmist warnings about the dangers of waiting too long.

In Ready, Elizabeth Gregory tracks the burgeoning trend of new later motherhood and demonstrates that for many women today, waiting for family works best.

She provides compelling evidence of the benefits of having children later -- by birth or by adoption.

Image: Buy Now on Amazon.comPaperback: 336 pages
Click to order/for more info: Ready - US | CDN | UK

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About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

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