When progesterone supplementation is given to a mother, its half life in the blood is very short.
In four minutes it begins to be excreted rapidly into the urine.
The most efficient route to take the progesterone to insure the best blood levels and the longest survival of the progesterone in the blood is to use vaginal suppositories.
The next best route of administration is to take injections of progesterone.
The least effective is to take the progesterone by mouth.
Full article: repro-med.net
A prospective randomized comparison of intramuscular or intravaginal natural progesterone as a luteal phase and early pregnancy supplement
-- A luteal phase defect has been demonstrated in cycles stimulated using a protocol including a gonadotrophin releasing hormone agonist (GnRHa). We have conducted a randomized prospective study of luteal and early pregnancy supplementation in 262 women selected for in-vitro fertilization (IVF), gamete intra-Fallopian transfer (GIFT) or zygote intra-Fallopian transfer (ZlFT). Either intramuscular progesterone in oil (50 mg/day) or intravaginal micronized progesterone (600 mg/day) was used as luteal supplement. In association with oestradiol valerate, progesterone administration was initiated from the day before oocyte retrieval until the 12th week of pregnancy. The implantation rate just failed to reach statistical significance (P = 0.07) in favour of the group receiving intravaginal progesterone. In the latter group, we observed a higher clinical pregnancy rate (33.6 versus 26.7%, not significant). Despite lower plasma progesterone levels, a lower first trimester abortion rate (P greater than 0.05) was found in the intravaginally treated group. Intravaginal micronized progesterone was well tolerated by all patients and appeared more effective than intramuscular progesterone in improving the implantation rate, and in decreasing the incidence of abortions in stimulated cycles including GnRHa.
Comparison between different routes of progesterone administration as luteal phase support in infertility treatments
-- Different routes of natural progesterone supplementation have been tried as luteal phase support in infertility treatments. Orally administered progesterone is rapidly metabolized in the gastrointestinal tract and its use has proved to be inferior to i.m. and vaginal routes. Progesterone i.m. achieves serum progesterone values that are within the range of luteal phase and results in sufficient secretory transformation of the endometrium and satisfactory pregnancy rates. The comparison between i.m. and vaginal progesterone has led to controversial results as regards the superiority of one or the other in inducing secretory endometrial transformation. However, there is increasing evidence in the literature to favour the use of vaginal progesterone. Vaginally administered progesterone achieves adequate endometrial secretory transformation but its pharmacokinetic properties are greatly dependent on the formulation used. After vaginal progesterone application, discrepancies have been detected between serum progesterone values and histological endometrial features. Vaginally administered progesterone results in adequate secretory endometrial transformation, despite serum progesterone values lower than those observed after i.m. administration, even if they are lower than those observed during the luteal phase of the natural cycle. This discrepancy is indicative of the first uterine pass effect and therefore of a better bio availability of progesterone in the uterus, with minimal systematic undesirable effects.
Photo credit: Bundle of Joy - This is a series of my baby boy Kian, by Bianca Venter, on FreeImages.com
All rights reserved
TODAY'S BOOK SUGGESTION:
You Can Get Pregnant Over 40, Naturally:
Overcoming infertility and recurrent loss in your late 30's and 40's naturally
by Sandy Robertson
-- Feeling physically, emotionally and financially drained after years of fertility treatments, Sandy Robertson started researching natural methods to enhance fertility.
This led to a specific pregnancy protocol which includes how she conceived multiple times over the age of 40 with only one fallopian tube, overcame recurrent pregnancy loss, balanced hormones, increased pelvic circulation, practiced visualization and meditation, reduced stress, and found support.
Click to order/for more info: You Can Get Pregnant Over 40, Naturally (US)
• Follow us on Twitter, join the conversation on our Facebook page, circle us on Google+, follow our pins on Pinterest.
More "Pregnancy Over 40" blogs to visit:
• Life Begins... - Pregnancy stories of loss, hope and help
• Pregnancy Stories by Age - Daily blog of hope and inspiration!
• You Can Get Pregnant in Your 40's - Sharing articles, discussing options and suggestions
• Stories of Pregnancy and Birth over 44 - sharing news stories I find online, for inspiration!