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Taking Soy and Clomid together

Catherine McDiarmid-Watt | Monday, January 04, 2021 | 0 comments

Image: woman pregnant belly baby outdoors pregnancy, by Lisa Runnels on Pixabay

Found on the Soulcysters message board:

My doctor has me taking 200 mg of soy cycle day 1-5 and then 150mg of Clomid cycle day 5-9.

I am taking the soy in the morning and the Clomid in the evening, so that on cycle day 5 I will take 200 mg of soy in the morning and 150mg of Clomid in the evening. I am to start OPK's [ovulation prediction kit] on cycle day 12 at 10am.

When I get a positive, I will go in for an ultrasound to check my lining and my follies, and then I will do an IUI [intra-uterine insemination] at 12 PM the following day, take another OPK [ovulation prediction kit] that day before the IUI, and if it is positive still, then I will get one more IUI done the 24 hours after the first one.

My doctor actually explained it well by saying that the photoestrogens in the soy will be estrogenic and cause my lining to thicken to counteract the Clomid's thinning, it will also give my eggs an estrogenic boost to ripening, so that I will ovulate sooner.

He also said that if we weren't doing an IUI cycle, the soy would be helpful in making a lot of good quality EWCM [egg white cervical mucus].

My doctor did do a small study with 200 women on 100 mg of Clomid - 100 with soy and 100 without. All of the women had to have proven ovulation with Clomid.

Here were his results:

In the women taking Clomid without/with soy:

• average uterine lining thickness : 7.5mm/11.3mm
• average number of mature (20mm or larger) follicles: 2.5/3.5
• average number of released follicles: 2/3
• percent of women that ovulated (verified by ultrasound and progesterone blood testing): 87%/93%
• average day of ovulation: 18/15
• average level of serum progesterone 10 days after ovulation: 9.3/12.2
• percent of ovulating women becoming pregnant with IUI over a course of three cycles (blood hcg levels greater than 5): 43.6%/68.7%
• percent of women that became pregnant that went on to give birth: 52.3%/89.7%


Soy isoflavones are contraindicated in those who are hypersensitive to any component of a soy isoflavone-containing product.

Pregnant women and nursing mothers should avoid the use of soy isoflavone supplements pending long-term safety studies. Men with prostate cancer should discuss the advisability of the use of soy isoflavones with their physicians before deciding to use them.

Women with estrogen receptor-positive tumors should exercise caution in the use of soy isoflavones and should only use them if they are recommended and monitored by a physician.

Soy isoflavone intake has been associated with hypothyroidism in some.

NOTE: This post has been created for informational purposes only. This post is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

Image: Zita West's Guide to Fertility and Assisted Conception: Essential Advice on Preparing Your Body for IVF and Other Fertility Treatments, by Zita West. Publisher: Random House UK (April 12, 2010)
Zita West's Guide to Fertility and Assisted Conception: Essential Advice on Preparing Your Body for IVF and Other Fertility Treatments
by Zita West

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About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

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