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Mutation causing one type of male infertility found

Catherine McDiarmid-Watt | Friday, July 24, 2009 | 0 comments

Mutation causing one type of male infertility foundResearchers have found a genetic mutation that lies behind one type of male infertility and may have been a cause of unsuccessful In-Vitro Fertilization (IVF) treatments in some couples.

The mutation lies in one specific protein present in sperm called PLC zeta. Recent research, in which the Oxford team also played a significant role, has shown that sperm transfers PLC zeta to the egg on fertilisation. The protein initiates a process called 'egg activation' which sets off all the biological processes necessary for development of the embryo.

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About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

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