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LH estrogen decreased in older women

Catherine McDiarmid-Watt | Wednesday, June 25, 2008 | 0 comments

Picture by stfroebel
Luteal phase estrogen is decreased in regularly menstruating older women compared with a reference population of younger womenLuteal phase estrogen is decreased in regularly menstruating older women compared with a reference population of younger women.

Objective: To compare daily reproductive hormone secretion in regularly menstruating older versus younger women.

Results: Daily morning urine samples were obtained from 106 women, 28 of whom were aged between 20 and 34 years (mean: 27.8 +/- 3.7 y) and 78 of whom were aged between 35 and 50 years (mean: 40.3 +/- 3.7 y). Lower luteal estrone-3-glucuronide levels were seen in the older versus the younger group (82.7 vs 93.5 ng/ml, P = 0.035).


The pregnanediol-3-glucuronide levels in the older group were lower than those in the younger group throughout the entire cycle. The median length of the follicular phase was shorter in the older versus younger women (13 vs 14.5 d, P = 0.005). There was no significant difference in the median luteal phase lengths between groups.

Conclusions: We report the new finding that regularly menstruating older women not only have lower pregnanediol-3-glucuronide levels but also have a significant reduction in luteal phase estrone-3-glucuronide compared with a contemporaneous cohort of younger women. This combined deficit may play a key role during the luteal-follicular transition, potentially affecting follicle recruitment and decreasing fecundity in the subsequent cycle.

(C)2008The North American Menopause Society


Full Article: http://www.menopausejournal.com/pt/re/menopause/fulltext.00042192-200815030-00015.htm;jsessionid=Lb8GpBcNZc8LZJDPwtyNYv5Ynp8wzSnkHYzPkY4b1pwXfTcJhKHB!1955444924!181195629!8091!-1


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Catherine

About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

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