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Folic acid supplementation affects the maturing oocyte

Catherine McDiarmid-Watt | Sunday, October 14, 2007 | 0 comments

Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans.

OBJECTIVE: To investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle

SETTING: Tertiary referral fertility clinic at the Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

PATIENT(S): Thirty-seven women undergoing IVF or intracytoplasmic sperm injection treatment.

INTERVENTION(S): No interventions other than routine stimulation treatment and the recommendation of folic acid supplementation.

MAIN OUTCOME MEASURE(S): Concentrations of folate and total homocysteine in monofollicular and pooled follicular fluid and the diameter of the follicle.

RESULT(S): Folic acid supplementation significantly increased folate and decreased total homocysteine concentrations in pooled follicular fluid. In monofollicular fluid, folate concentrations only were significantly increased in supplemented women. The total homocysteine concentration appeared to be significantly correlated with the diameter of the follicle (r = 0.27). Samples from single follicles were less prone to artifacts in the measurements of the folate and total homocysteine concentration.

CONCLUSION(S): Preconception folic acid supplementation significantly alters both folate and total homocysteine concentrations in follicular fluid. The correlation between the diameter of the follicle and total homocysteine concentration in follicular fluid warrants further investigation.


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About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

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