A new study led by scientists from the US Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) found that a healthy intake of micronutrients is strongly associated with improved sperm DNA quality in older men. In younger men, however, a higher intake of micronutrients didn't improve their sperm DNA.
In an analysis of 80 healthy male volunteers between 22 and 80 years of age, the scientists found that men older than 44 who consumed the most vitamin C had 20% less sperm DNA damage compared to men older than 44 who consumed the least vitamin C. The same was true for vitamin E, zinc, and folate.
"It appears that consuming more micronutrients such as vitamin C, E, folate and zinc helps turn back the clock for older men. We found that men 44 and older who consumed at least the recommended dietary allowance of certain micronutrients had sperm with a similar amount of DNA damage as the sperm of younger men," says Andy Wyrobek of Berkeley Lab's Life Sciences Division.
Men at risk of sperm DNA damage
"This means that men who are at increased risk of sperm DNA damage because of advancing age can do something about it. They can make sure they get enough vitamins and micronutrients in their diets or through supplements," adds Wyrobek.
Wyrobek conducted the research with a team of researchers that includes Brenda Eskenazi of the University of California at Berkeley's School of Public Health and scientists from the University of Bradford in the United Kingdom. They report their findings in the online issue of the journal Fertility and Sterility.
Their research comes as more men over 35 have children, which raises public health concerns. Previous research conducted in Wyrobek's lab found that the older a man is, the more he's likely to have increased sperm DNA fragmentation, chromosomal rearrangements, and DNA strand damage. Older men are also more likely to have increased frequencies of sperm carrying certain gene mutations, such as those leading to dwarfism.
Findings in study
These findings help explain why ageing men are less fertile and are predicted to have more chromosomally defective pregnancies and a higher proportion of offspring with genetic defects. But until now, researchers haven't understood whether diet can protect against the detrimental effects of ageing on the sperm genome.
The scientists studied a group of about 80 men between 20 and 80 years old with an average age of 44. They were recruited several years ago as part of the California Age and Genetic Effects on Sperm Study when Wyrobek was at Lawrence Livermore National Laboratory. Each man who participated in the study filled out a 100-item questionnaire that estimated their average daily vitamin intake, both from food and supplements.
In addition, their sperm DNA quality was assessed via a lab analysis in which a voltage gradient pulls broken DNA strands from intact strands within the sperm nucleus.
Each volunteer's intake of a micronutrient was classified as low, moderate, or high based on how they compared to other participants. The median daily intake, both from diet and supplements, was 162 milligrams for vitamin C, 23.7 milligrams for vitamin E, 2,586 micrograms for β-carotene, 475 grams for folate, and 12.3 milligrams for zinc. Many participants, even those who reported to be healthy, consumed much less than the recommended dietary allowance for many of the micronutrients.
Scientists discussed data
The scientists analysed the data several ways and came up with the same result each time. A diet high in antioxidants and micronutrients may decrease the risk of producing sperm with DNA damage, especially in older men.
Why this is so isn't a mystery. Antioxidants scavenge reactive molecules that cause oxidative damage to cells. Studies have shown that dietary supplementation with antioxidants and increased consumption of antioxidant-rich fruits and vegetables can decrease the amount of oxidative DNA damage.
Based on their results, the scientists believe this same protective mechanism may also be at work in the reproductive tract of older men. "The different response of the old and young men presents new opportunities for health care, especially for older men planning families," says Wyrobek.
More research is needed, however. Although the scientists found a clear link between higher vitamin intake and improved sperm DNA quality in older men, they don't know whether this link extends to male fertility and the health of offspring.
"Our research points to a need for future studies to determine whether increased antioxidant intake in older fathers will improve fertility, reduce risks of genetically defective pregnancies, and result in healthier children," says Wyrobek. "The research also raises a broader question beyond sperm DNA: How might lifestyle factors, including higher intakes of antioxidants and micronutrients, protect somatic as well as germ cells against age-related genomic damage?"
(EurekAlert, August 2012)
Study - Micronutrients intake is associated with improved sperm DNA quality in older men
Photo credit: sciencedirect.com
All rights reserved
TODAY'S BOOK SUGGESTION:
Overcoming Male Infertility
by Leslie R. Schover and Anthony J. Thomas Jr.
-- Hope and strategies for couples dealing with male infertility If you or your partner is suffering from male infertility, you're not alone.
Millions of couples are struggling with this problem. About 40% of these couples have exclusively male in-fertility problems, while another 20% have both male and female infertility problems.
Now, two leading experts, a urologist specializing in male infertility and a psychologist, team up to write the most complete guide available on male infertility.
From the latest, state-of-the-art treatments to advice on how to handle the emotional aspects of male infertility, you'll find out where to get the help you need.
Overcoming Male Infertility also covers the psychological issues that are unique to men, and gives advice to women on helping their man through the trauma of infertility treatment--including how to get him to see a doctor in the first place.
Paperback: 304 pages - Click to order/for more info: Overcoming Male Infertility
US | Canada | UK
-- Start reading Overcoming Male Infertility on your Kindle in under a minute!
Don't have a Kindle? Get your Kindle here, or download a FREE Kindle Reading App.
• Follow us on Twitter, join the conversation on our Facebook page, circle us on Google+, follow our pins on Pinterest.
More Frugal Blogs and Websites:
• Born to Love: All your cloth diapering needs, and much more - naturally! We are strong advocates of the personal, social and environmental benefits of natural parenting.
• Frugal Freebies: Keep up with the latest free stuff, deals, coupons, and other ways to save money!
• My Frugal Baby Tips: Taking care of baby and mom needs naturally, does not have to cost a whole lot of money!
• Life Begins... - Pregnancy stories of loss, hope and help
• Pregnancy Stories by Age - Daily blog of hope and inspiration!
• You Can Get Pregnant in Your 40's - Sharing articles, discussing options and suggestions
• Stories of Pregnancy and Birth over 44 - sharing news stories I find online, for inspiration!