Amazon.com lists over 11,000 items under the search term "fertility"

Hope for men with nonobstructive infertility

Catherine McDiarmid-Watt | Tuesday, December 08, 2009 | 0 comments

Photo by i_sabel
Hope for men with nonobstructive infertilityIt has been thought that men with non-obstructive azoospermia (NOA), a lack of sperm in the semen not caused by an obstruction within the reproductive system, are poor candidates for IVF. Now, researchers writing in the open access journal Reproductive Biology and Endocrinology have shown that sperm from men with NOA and obstructive azoospermia (OA) are equally capable of producing embryos.

Nina Desai led a team of researchers from the Cleveland Clinic Foundation who carried out an in-depth analysis of intracytoplasmic sperm injection (ICSI) using frozen sperm taken from the testes of 44 men with OA and 17 men with NOA. They found that, although fertilization rates were slightly improved in the OA group, there were no significant differences in implantation rates or clinical pregnancy rates. According to Desai, "The high implantation rate per embryo transferred and the resultant live births attest to the quality of embryos being produced with both types of surgically retrieved sperm".


In addition to evaluating the feasibility of NOA sperm, the researchers were also able to study paternal effect on genomic activation. One of the earliest morphologic indicators of embryonic genome activation is increased cell-to-cell adherence at the 8-cell stage, leading to compaction. Desai said, "Interestingly, we found that embryonic compaction was similar in all three groups. These results suggest that zygotic activation is independent of sperm origin and type of azoospermia".


1. Paternal effect on genomic activation, clinical pregnancy and live birth rate after ICSI with cryopreserved epididymal versus testicular spermatozoa
Nina Desai, Faten AbdelHafez, Edmund Sabanegh and James Goldfarb
Reproductive Biology and Endocrinology (in press)

Source

Life Begins... - Miscarriage stories of loss, hope & help
Pregnancy Stories by Age - Daily blog of hope & inspiration!
Stories of Pregnancy over 44 years old - sharing stories I find online, for inspiration!


Recent Keyword Searches: can a woman get prgnant at 45 years old, 42 and trying to get pregnant, how likely is it for a menopausal woman to get pregnant, getting pregnant after 40, fertility in the over forty yars old woman





Category: , ,

Catherine

About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

Find Catherine on Google+ - Circle us on Google+ - Join us on Facebook - Follow us on Twitter

0 comments

WE LOVE COMMENTS!
Don't just sit there, reading this story or article - say something! Do you believe it? Do you think it is impossible? Do you wish it was you? Do you have a story to share (it might get published!)

NOTE: Comments are moderated - just to stop the spambots - and so may take up to a few hours to be approved.

Catherine reserves the right to review, edit, refuse or delete any comment.

Popular Posts