Endometrial thickness predicts IVF success
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| Photo Credit: Couple Holding Ultrasound, by Kelly Sikkema |
MedWire News: Initial changes to endometrial thickness could help identify those patients most likely to achieve IVF success, a US study suggests.
Grant McWilliams (Tripler Army Medical Center, Honolulu, Hawaii) and John Frattarelli (Reproductive Medicine Associates of New Jersey, Somerset) used transvaginal ultrasound to examine endometrial changes among 132 couples undergoing a fresh, autologous IVF cycle, of whom 70 conceived.
Pregnancy rates were lower with an endometrial thickness of less than 6 mm on the sixth day of gonadotropin stimulation (so after 6 days of taking fertility drugs) compared with greater thickness, at 38.0 versus 64.5 percent, respectively.
A difference in endometrial thickness between baseline pituitary suppression and the sixth day of gonadotropin stimulation of less than 2 mm was also linked to lower pregnancy rates than greater differences, at 42.0 versus 62.7 percent, respectively.
Pregnancy rates were also higher with an endometrial thickness of at least 8 mm on the day of human chorionic gonadotropin administration (this is the trigger shot), with a change from baseline of at least 3 mm, and no change from day 6 of gonadotropin stimulation.
The researchers suggest:
Continued use of transvaginal ultrasound to evaluate endometrial thickness and the change occurring during ovarian stimulation can aid providers in counseling patients and predicting IVF success.
Source: Fertility and Sterility 2007; 88: 74-81
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Category: IVF
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