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Impact of duration and dose on IVF outcomes

Catherine McDiarmid-Watt | Wednesday, December 16, 2015 | 1 comments

Image: The female hips have long been associated with both fertility and general expression of sexuality, by Lucas Cobb, on Flickr
In order to examine whether the duration of the follicular phase and changes in daily gonadotrophin dosages impact IVF outcome, a retrospective analysis of women who underwent oocyte retrieval and fresh embryo transfer was performed.

Among the parameters assessed were the number of days of gonadotrophin stimulation, changes in the daily dosage of gonadotrophins, total ampoules of gonadotrophins, embryo implantation rates, clinical pregnancy rates and ongoing pregnancy rates.

The number of days of gonadotrophin stimulation, as determined by standard follicular size criteria did not appear to influence IVF outcomes. There was no significant difference in pregnancy rates between women who were stimulated for less than 9 days, 10-11 days or more than 12 days.

When grouped by amount of starting daily dose of gonadotrophins there was a significant inverse relationship between gonadotrophin requirements and pregnancy rates (P=0.02).

The data suggest that the success of an IVF cycle depends on the ovaries' ability to develop follicles of the appropriate size, not the speed at which the ovaries perform this function.

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520-8063, USA.
by Martin JR, Mahutte NG, Arici A, Sakkas D.
PMID: 17169173 [PubMed - indexed for MEDLINE]
Source: Ncbi.nlm.nih.gov

Stock Photo credit: Female Hips
by Lucas Cobb, on Flickr

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TODAY'S BOOK SUGGESTION:
Image: The Infertility Cure: The Ancient Chinese Wellness Program for Getting Pregnant and Having Healthy Babies, by Randine Lewis. Publisher: Little, Brown and Company (March 21, 2005)-The Infertility Cure: The Ancient Chinese Wellness Program for Getting Pregnant and Having Healthy Babies
by Randine Lewis

-- Infertility affects one out of six couples today.

Dr. Lewis presents a groundbreaking alternative approach to infertility, explaining how she used traditional Chinese medicine to treat her own infertility, successfully conceiving and giving birth to two children.

In Lewis's experience, women who have undergone three to six months of the dietary changes, herbs and acupuncture treatments become pregnant with no further effort.

Lewis intersperses her somewhat technical examination of the program with anecdotes about her patients, weaving in discussions on diet, herbal supplements, acupuncture, older women and problems related to infertility.

Image: Buy Now on Amazon.comPaperback: 320 pages
Click to order/for more info: The Infertility Cure







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Catherine

About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.

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1 comments

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