You Can Get Pregnant in Your 40's: July 2008

Found this post on FertilityFriends.com :

"This is a compilation of high FSH success stories put together by someone on a high FSH support board. This is highly unscientific, but it seems like even accounting for error and lack of randomization, the typical RE speech that says you have less than 5% chance of becoming pregnant with high FSH seems incorrect. It seems more like you have nearer to a 30% chance.

I thought this might be interesting to some of you ladies:

http://spreadsheets.google.com/pub?key=peJpwrLxiXLQGnQE9_m9EYw

Also, there is more info about high FSH on this place:
http://www.highfshinfo.com/#soihavehighfsh

Source: http://www.fertilityfriend.com/Circles/viewtopic.php?t=1588977

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LOS ANGELES, July 22, 2008 (PRIME NEWSWIRE) -- East West Essentials, a leader in optimal fertility supplements, is offering their highly successful Female Fertility Kit online to customers worldwide. The 30-day supplement program, developed by renowned fertility specialist Dr. Jeanne Wilson, Ph.D, L.Ac., is now available through the company website at www.eastwestessentials.com .

In the United States this year, between seven to nine million couples will confront infertility related issues. East West Essentials' Female Fertility Kit provides women with a safe, natural, high quality supplemental program that achieves real clinical results. It can help women retain reproductive health, create an environment to enhance fertility, reduce the risk of complications during pregnancy and support the growth of healthy babies.

Dr. Wilson's approach combines proven Eastern and Western medical techniques to enhance a patient's reproductive health and chance for a healthy baby. With success rates between 60 and 70 percent in her clinics, she has created a supplemental program that supplies specific nutritional assistance that is designed to increase each patient's ability to conceive.

"I've been in practice for a long time, and I take the success of my patients very personally," said Dr. Wilson. "The East West Essentials' Female Fertility Kit has been developed for patients that struggle to have a family."

The Fertility Kit has enjoyed success in the lives of medical professionals as well. "I was introduced to East West supplements by an Ob/Gyn who recommended it for my pregnancy," said Dr. Shadiar Ohadi, a Family Practitioner from Burbank, California. "I recommend it to my patients quite often because I had such a wonderful experience."

East West Essentials' clinically proven Female Fertility Kit addresses a body that is out of balance due to overwork, stress, exhaustion and lack of nutrients in the diet. Through the use of vitamins, minerals, fatty acids and other fertility enhancing nutrients, this kit provides fundamental support to return a healthy balance to a woman's body. Each kit is tested and examined for quality assurance, and East West Essentials' Female Fertility Kit goes above and beyond FDA standards.

East West Essentials' Female Fertility Kit can be obtained both domestically and internationally through referral by leading Ob/Gyns and reproductive endocrinologists, as well as IVF doctors. The kit can also be purchased online at http://www.eastwestessentials.com/ , toll free at 800-914-0919, or over the counter at available pharmacies.

Source: http://www.primenewswire.com/newsroom/news.html?d=146796

TODAY'S BOOK SUGGESTION:

Image: My Baby Chase: Our Roller Coaster Ride from Infertility to Parenthood, by Gilda Dangot Simpkin (Author). Publisher: Dog Ear Publishing (August 29, 2017)

My Baby Chase: Our Roller Coaster Ride from Infertility to Parenthood
by Gilda Dangot Simpkin

-- This is the heart-wrenching tale of our convoluted 10-year quest to have a family, from the serious, and sometimes hilarious side of fertility treatments, through two harrowing international adoptions. Our journey is filled with so many cliff hangers it reads more like a suspense tale than reality.

As you come along for our wild ride you will be clutching this book praying we don't get derailed again.

Our story of determination and tenacity will give hope to anyone facing a difficult life journey.

Let my story motivate you to attain your dreams!

Paperback: 188 pages
Click to order/for more info: My Baby Chase

Start reading My Baby Chase on your Kindle in under a minute!

Don't have a Kindle? Get your Kindle here, or download a FREE Kindle Reading App.

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Infertile men can have a fair chance to be fertile by simply going through a painless invasive treatment that can significantly improve a couple's chance for pregnancy.

For this treatment, instead of going through an open surgery, which was the only known method yet, the patient will go through a retrograde venous embolization - a simple treatment that uses a catheter through the groin.

The treatment can help to improve sperm function in infertile men. The researchers also found that success of the treatment can also be predicted by the level of sperm motility.

Full Story: http://www.newstrackindia.com/newsdetails/8241

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Soy products contain chemicals mimicking female hormones

A regular diet of even modest amounts of food containing soy may halve sperm concentrations, suggest scientists.

The study, published in the journal Human Reproduction, found 41 million fewer sperm per millilitre of semen after just one portion every two days.

The authors said plant oestrogens in foods such as tofu, soy mince or milk may interfere with hormonal signals.

SEE ALSO
Being too fat 'can damage sperm' 09 Jul 08 Health
Paint chemicals 'may harm sperm' 23 May 08 Health
Coffee 'worsens poor fertility' 07 Jul 08 Health

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Q. How did you become interested in fertility issues? What percent of your practice deals with fertility issues?

A. I became interested in fertility issues after finding that (infertility) was increasing in the population at an alarming rate -- and it was a common complaint with my patients since I specialized in women's health disorders.

Since Western-medical fertility treatments are usually not covered by health insurance, and in vitro fertilization (IVF) cycles can cost from $10,000 to $15,000, I thought it was reasonable to offer Chinese medicine to those who couldn't afford IVF cycles and to offer it to those undergoing IVF to help increase their success rates.

Full story: http://www.news-leader.com/apps/pbcs.dll/article?AID=/20080721/LIFE04/807210312

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Montreal, July 17, 2008 – A group of Canadian and European researchers have unlocked the mystery of a gene with the potential to both regulate and block ovulation. The new study – a collaboration between the Université de Montréal in Canada and the Institut de génetique et biologie moléculaire et cellulaire of the Université de Louis Pasteur, Strasbourg, France – is published in the latest issue of the journal Genes & Development.

"Our findings demonstrate that the Lrh1 gene is essential in regulating ovulation," said Bruce D. Murphy, director the Animal Research Centre at the Faculty of Veterinary Medicine and an adjunct professor of and obstetrics and gynaecology at the Faculty of Medicine of the Université de Montréal. "Until this point, the role of Lrh1 in female fertility was unclear, but we have found the gene regulates multiple mechanisms of ovulation and may affect fertilization."

To reach their conclusions, the research team developed a new type of genetically modified mouse whose Lrh1 gene was selectively blocked in the ovary. They found that deletion of the Lrh1 gene effectively stopped ovulation. "This discovery means we can envision new contraceptives that selectively stop ovulation," said Dr. Murphy. "If created, these new contraceptives would be more effective and produce less side-effects than current steroid-based forms of birth control."

What's more, the findings could lead to the development of pharmaceuticals that activate the Lrh1 gene, which may prove critical in giving infertile couples hope in producing children. "This is an important development, since 15 percent of couples are infertile," said Dr. Murphy. "The widespread role of this gene in the ovary indicates that it may be targeted to stimulate ovulation and, eventually, conception."

Source: http://www.eurekalert.org/pub_releases/2008-07/uom-rda071708.php

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19 July, 2008 - This month Danish scientists reported results from a 10-year study that showed children born from previously frozen embryos that had been replaced in the womb had higher birth weight than those born when fresh embryos were used.

The mothers had longer pregnancies, and the children did not show increased risk for birth defects, according to Dr. Anja Pinborg of the Copenhagen University Hospital Rigshospitalet who presented the results at the European Society of Human Reproduction and Embryology annual conference in Barcelona July 8.

Source: http://www.fleshandstone.net/healthandsciencenews/embryos.html

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Patricia Rashbrook became Britains oldest mother after giving birth at 63

Women who are over 50 should have the right to fertility treatment, a top British scientist said today.

Professor Ian Craft said those opposed to older women becoming mothers are guilty of a 'police state mentality'.

The controversial doctor from the London Fertility Centre told a meeting of fertility experts that women have given birth after the menopause, which justifies giving those in their fifties IVF treatment.

Professor Craft, whose clinic helped a 56-year-old woman get pregnant, said: 'Knowing that natural conceptions do occur, why should infertile women be denied treatment that occurs naturally, whether they still menstruate or not?

Full story: http://www.dailymail.co.uk/health/article-1033366/Over-50s-right-IVF-says-fertility-doctor.html

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The Parents Via Egg Donation Organization, or PVED, was created to provide an informational and supportive environment where parents and parents-to-be can come together to exchange information about all facets of the egg donation process.

Our mission and purpose is to educate, support, and empower families and individuals at any stage of the process who choose to use egg donation to build a family.

We plan to offer information regarding agencies, legal and medical professionals, treatment centers, mental health therapists, pharmaceutical companies, and other resources.

Wherever you are in the process, there is always a place in our community for you

Parents Via Egg Donation
http://parentsviaeggdonation.org
http://tpvedo.blogspot.com

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The methods for assessing ovarian reserve are classified into two groups: passive testing and dynamic testing. The goal of both approaches is to provide information regarding oocyte (egg) quality and quantity. We'll begin this section by examining passive testing methods.

As clinicians gained experience with IVF in the 1980's, it became apparent that early follicular-phase FSH levels played an important role in pregnancy outcomes. We soon discovered that day 3 FSH (measured by a blood test) could be very useful in predicting response to ovulation induction and IVF.

As a woman ages, FSH becomes elevated in an attempt to force the aging ovary to respond. However, the exact mechanism responsible for this adaptive response remains unknown. A rise in early follicular-phase FSH is also accompanied by a decline in oocyte quality, and some investigators have linked such FSH elevations to fetal abnormalities. In fact, it has been theorized that subtle but measurable increases in FSH precede menopause by approximately five years in some women

Full article: http://www.ivf.com/ovarianreserve.html#fsh

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Children born from frozen embryos weigh more and do better than those born after fresh transfer

Barcelona, Spain: Children born after a frozen, thawed embryo has been replaced in the womb have higher birth weight than those born where fresh embryos were used, Danish scientists reported to the 24th annual conference of the European Society of Human Reproduction and Embryology today (Tuesday 8 July). The mothers had longer pregnancies, and the children did not show an increased risk of congenital malformations, said Dr. Anja Pinborg, from the Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

in Biological Science via EurekAlert! @ 11:47 8th Jul - Related

Source: http://bigblog.com/biological_science/children-born-from-frozen-embryos-weigh-more-and-do-better-than-those-born-after-fresh-transfer-1494457307.html

Babies From Frozen Embryo Just As Healthy: Study

Published on July 9, 2008

Using frozen embryos in place of fresh ones during IVF procedures produces healthier babies with higher birth weight and lesser abnormalities, a new Danish study reports.

The findings of the study presented at a meeting of the European Society of Human Reproduction and Embryology on Tuesday provided strong evidence stating that babies born from frozen embryos were just as healthy as those conceived naturally.

The team of Danish researchers monitored medical records of nearly over 1,200 children born in Denmark between 1995 and 2006 using frozen embryos technique. Also monitored were nearly 18,000 children born from fresh embryos during the same period.

Upon comparison of medical records between the two groups of infants born using different techniques, the babies in the frozen embryo group weighed about 200 grams more at time of birth and also had a lesser percentage of pre-term births as compared to the other group, the Danish researchers found.

Also, frozen embryo technique did not increase the risk of congenital birth defects among infants. The congenital birth defects rate in the frozen embryo group was 7.1 per cent compared to 8.8 per cent where fresh embryos had been used. Moreover, fewer newborns required immediate medical support or admission to neonatal intensive care units, researchers found.

"According to this study, which is currently the largest on frozen embryo replacement offspring, these children perform as ... offspring after fresh embryo transplant or even better," the researchers remarked.

‘The strongest embryos survived the freezing process’ researchers of the study said while explaining why frozen embryos produced better results than the ‘fresh’ ones.

Freezing embryos, a well-established form of assisted conception treatment saves eggs for future use. Embryos are stored in liquid nitrogen at a temperature of minus 196º C for up to five years. Stored at such low temperature they are in a state of suspended animation where all metabolic activity is halted.

Source: http://www.themedguru.com/articles/babies_from_frozen_embryo_just_as_healthy_study-8615814.html

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Pregnancy is predictable: a large-scale prospective external validation of the prediction of spontaneous pregnancy in subfertile couples.

BACKGROUND: Prediction models for spontaneous pregnancy may be useful tools to select subfertile couples that have good fertility prospects and should therefore be counselled for expectant management. We assessed the accuracy of a recently published prediction model for spontaneous pregnancy in a large prospective validation study.

METHODS: In 38 centres, we studied a consecutive cohort of subfertile couples, referred for an infertility work-up. Patients had a regular menstrual cycle, patent tubes and a total motile sperm count (TMC) less than 3 x 10(6). After the infertility work-up had been completed, we used a prediction model to calculate the chance of a spontaneous ongoing pregnancy ( www.freya.nl/probability.php ).

The primary end-point was time until the occurrence of a spontaneous ongoing pregnancy within 1 year. The performance of the pregnancy prediction model was assessed with calibration, which is the comparison of predicted and observed ongoing pregnancy rates for groups of patients and discrimination.

CONCLUSIONS: As the chance of a spontaneous ongoing pregnancy among subfertile couples can be accurately calculated, this prediction model can be used as an essential tool for clinical decision-making and in counselling patients. The use of the prediction model may help to prevent unnecessary treatment.

Full article: http://www.ncbi.nlm.nih.gov/pubmed/16997935

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I tried doing some calculations for a 48 year old woman (oldest age they list) and got:

The calculated probability of a spontaneous ongoing pregnancy within one year is: 36.1%
__________________________________

Note the page says:
This probability is not reliable in case of :

* - Women with ovulation disorders
* - Men with severe male factor (Total motile sperm count = volume x concentration x % motility <>
* - Women with 2-sided tubal pathology.

Try it out at: http://www.freya.nl/probability.php and let me know what you get!

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Part of a growing trend: John Preston with Joseph and Amelia

Despite the higher risk of baby fathered by an older man having autism or Down's Syndrome, older fathers may well be better for their offspring than their younger counterparts.

'What's it like, then?" people have been asking me a lot recently, usually with a peculiar lop-sided grin on their faces. "What's what like?" I reply, staring at them as blankly as possible.

A look of mild embarrassment comes over all but the thickest skinned of them, and they drop their voices down to a tactful mumble. "Well, you know… being an older dad."

Full story: http://www.telegraph.co.uk/news/2130834/Do-older-men-make-better-dads.html

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