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bies
Here are some of the methods that can help older women conceive - and the chances of success...
Natural conception
It's harder to conceive naturally after 35, but it's by no means impossible. You can improve your chances by having sex mid-cycle to coincide with your most fertile time. (Chemists stock testing kits that reveal when you ovulate.) You should also be a healthy weight, exercise and take a folic acid supplement.
See http://www.mothers35plus.co.uk/
Pros: No medical intervention.
Cons: You may waste time better spent trying fertility treatments.
Your Chances: "Over 40, your chances of conceiving naturally are only 20 per cent" says Dr Lockwood.
"This is even lower if you've had cancer treatment. Chemo adds 10 years to your reproductive age."
Fertility drugs
Drugs such as Clomid are used to increase egg production, but aren't usually offered to women in their late 30s or 40s as they don't improve egg quality.
Pros: It's safe, cheap and easy to administer.
Cons: The drug can make cervical mucus hostile to sperm and impair egg implantation.
Your Chances: "If you are not producing enough eggs - say, due to polycystic ovary syndrome - your chances are reasonable," says Dr Lockwood. "But Clomid isn't very good for age-related infertility as the real issue is egg quality."
IVF
Fertility drugs increase your egg production. The eggs are then removed and sperm is added in a test tube. Fertilised embryos are then put back into the womb.
Pros: It can work where other treatments fail.
Cons: It's timeconsuming and expensive (between £2,000-£4,000).
The egg extraction process can be painful and fertility drugs can cause PMS-like symptoms.
Your Chances: Dr Lockwood says: "IVF for women over 40 is disappointing if it uses the woman's own eggs. Pregnancy rates are lower and miscarriage rates are higher.
"A woman over 40 has only half the chance of a live birth after IVF compared to a woman under 38. And if you've had chemo your chances are less than 10 per cent."
Donor eggs
If your eggs aren't viable, you could use a donor's.
Pros: You carry the baby.
Cons: The baby isn't related to you biologically, and you still have to go through costly, stressful IVF.
Your Chances: "Excellent," says Dr Lockwood. "The age of the donor determines the success rate.
However, patients receiving donor eggs are required to take hormone replacement therapy (HRT), so cancer survivors will have to wait up to five years following their all-clear."
This is because HRT may increase the risk of hormone-related cancers.
Ovarian tissue Cryo-preservation
Kylie is rumoured to have undergone this procedure, which aims to preserve the fertility of women needing cancer treatment.
A sliver of ovary is removed and frozen then it's later put back inside the patient in the hope that some of her eggs will have been preserved.
Pros: It gives fertility hope to women battling cancer.
Cons: It's a very new and experimental procedure.
Your Chances: "So far only two babies have been born worldwide from slices of ovary that were retransplanted back after chemo," says Dr Lockwood. "But there are hopes for it in the future."
Egg freezing
Your eggs can be frozen - preferably before you are 35 - to be used at a later date. This is offered on the NHS to patients having cancer treatment, and women can pay to do it as a lifestyle choice.
When you want to conceive, the eggs are mixed with your partner's sperm then planted in your womb.
Pros: This procedure is a more realistic chance for older women to conceive, and gives you greater control over your fertility.
Cons: It's invasive, expensive (prices start at £2,000) and doesn't guarantee a pregnancy.
Your Chances: "Egg freezing before cancer treatment does offer a realistic chance of pregnancy, especially if the woman is young," says Dr Lockwood. "But after 38 it's less successful simply because the quality of eggs deteriorates."
Full article: http://www.mirror.co.uk/showbiz/yourlife/2008/02/06/kylie-s-baby-race-and-how-you-can-conceive-at-40-89520-20310940/
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biesHere are some of the methods that can help older women conceive - and the chances of success...
Natural conception
It's harder to conceive naturally after 35, but it's by no means impossible. You can improve your chances by having sex mid-cycle to coincide with your most fertile time. (Chemists stock testing kits that reveal when you ovulate.) You should also be a healthy weight, exercise and take a folic acid supplement.
See http://www.mothers35plus.co.uk/
Pros: No medical intervention.
Cons: You may waste time better spent trying fertility treatments.
Your Chances: "Over 40, your chances of conceiving naturally are only 20 per cent" says Dr Lockwood.
"This is even lower if you've had cancer treatment. Chemo adds 10 years to your reproductive age."
Fertility drugs
Drugs such as Clomid are used to increase egg production, but aren't usually offered to women in their late 30s or 40s as they don't improve egg quality.
Pros: It's safe, cheap and easy to administer.
Cons: The drug can make cervical mucus hostile to sperm and impair egg implantation.
Your Chances: "If you are not producing enough eggs - say, due to polycystic ovary syndrome - your chances are reasonable," says Dr Lockwood. "But Clomid isn't very good for age-related infertility as the real issue is egg quality."
IVF
Fertility drugs increase your egg production. The eggs are then removed and sperm is added in a test tube. Fertilised embryos are then put back into the womb.
Pros: It can work where other treatments fail.
Cons: It's timeconsuming and expensive (between £2,000-£4,000).
The egg extraction process can be painful and fertility drugs can cause PMS-like symptoms.
Your Chances: Dr Lockwood says: "IVF for women over 40 is disappointing if it uses the woman's own eggs. Pregnancy rates are lower and miscarriage rates are higher.
"A woman over 40 has only half the chance of a live birth after IVF compared to a woman under 38. And if you've had chemo your chances are less than 10 per cent."
Donor eggs
If your eggs aren't viable, you could use a donor's.
Pros: You carry the baby.
Cons: The baby isn't related to you biologically, and you still have to go through costly, stressful IVF.
Your Chances: "Excellent," says Dr Lockwood. "The age of the donor determines the success rate.
However, patients receiving donor eggs are required to take hormone replacement therapy (HRT), so cancer survivors will have to wait up to five years following their all-clear."
This is because HRT may increase the risk of hormone-related cancers.
Ovarian tissue Cryo-preservation
Kylie is rumoured to have undergone this procedure, which aims to preserve the fertility of women needing cancer treatment.
A sliver of ovary is removed and frozen then it's later put back inside the patient in the hope that some of her eggs will have been preserved.
Pros: It gives fertility hope to women battling cancer.
Cons: It's a very new and experimental procedure.
Your Chances: "So far only two babies have been born worldwide from slices of ovary that were retransplanted back after chemo," says Dr Lockwood. "But there are hopes for it in the future."
Egg freezing
Your eggs can be frozen - preferably before you are 35 - to be used at a later date. This is offered on the NHS to patients having cancer treatment, and women can pay to do it as a lifestyle choice.
When you want to conceive, the eggs are mixed with your partner's sperm then planted in your womb.
Pros: This procedure is a more realistic chance for older women to conceive, and gives you greater control over your fertility.
Cons: It's invasive, expensive (prices start at £2,000) and doesn't guarantee a pregnancy.
Your Chances: "Egg freezing before cancer treatment does offer a realistic chance of pregnancy, especially if the woman is young," says Dr Lockwood. "But after 38 it's less successful simply because the quality of eggs deteriorates."
Full article: http://www.mirror.co.uk/showbiz/yourlife/2008/02/06/kylie-s-baby-race-and-how-you-can-conceive-at-40-89520-20310940/
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A cause of premature menopause has been found which could pave the way to new treatments and also help improve the success of test tube baby fertility treatments.
An international team that includes British scientists has discovered an enzyme that controls the rate at which women ovulate and believe that when this process goes awry it can lead to menopause occurring years earlier than normal.
At birth, the ovaries of women contain about 300,000 - 400,000 unripe eggs, her lifetime's complement, each held in a tiny sac or follicle.
But in adulthood only ten or so follicles grow each month and of these, only one goes on to deliver an egg bursting to release its ripened egg into the fallopian tube.
However, around one woman in every hundred runs out eggs before her 40th birthday, triggering early menopause, so she is no longer able to have children naturally.
Today, in the journal Science, Dr Kui Liu of Umeå University, Sweden, Prof Ilpo Huhtaniemi of Imperial College London and colleagues in China and America report that the enzyme PTEN keeps immature eggs from ripening prematurely. "It is a kind of brake," says Prof Huhtaniemi.
The team finds that in mice lacking PTEN in their eggs, the entire pool of immature eggs is activated prematurely, becoming ripe so the mouse uses up it store of eggs more rapidly..
Prof Huhtaniemi says that PTEN works in humans too and that the team is now going to investigate whether mutations in the PTEN gene are linked with premature menopause in women. "We have one good candidate to explain why some women develop premature menopause," he says.
A drug to mimic the effects of PTEN could be used to prevent or treat premature menopause when combined with new tests that can show how quickly a woman's biological clock is ticking. By the same token, a way to block the effects of PTEN could lead to new ways to ripen eggs for IVF, notably if eggs fail to ripen in the first place, says Dr Liu.
To overcome how women only make one egg each month and obtain more for IVF treatments, or to create embryos if they are to undergo fertility threatening cancer treatments, doctors have used expensive hormones to stimulate them to ripen multiple eggs, which does carry some risks.
But some women seeking to preserve their child-bearing capacity may not have enough time to undergo ovarian stimulation or may have a condition that makes it dangerous, such as hormone-sensitive breast cancer.
Lab-dish or "in vitro" egg maturation has produced hundreds of babies worldwide, though is still experimental.
Now PTEN offers another way to ripen eggs, says Dr Liu. "With the knowledge that PTEN suppresses follicle activation, it is in theory possible to culture a piece of the ovaries in the petri-dish and trigger the follicle growth with a synthetic PTEN inhibitor, which we have started to try".
Such a method will enrich the source of eggs for IVF or who want to freeze their embryos before going to have chemotherapy or radiation therapy for cancer, says Dr Liu.
Source: http://www.telegraph.co.uk/earth/main.jhtml?view=DETAILS&grid=&xml=/earth/2008/01/31/scimeno131.xml
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A cause of premature menopause has been found which could pave the way to new treatments and also help improve the success of test tube baby fertility treatments.An international team that includes British scientists has discovered an enzyme that controls the rate at which women ovulate and believe that when this process goes awry it can lead to menopause occurring years earlier than normal.
At birth, the ovaries of women contain about 300,000 - 400,000 unripe eggs, her lifetime's complement, each held in a tiny sac or follicle.
But in adulthood only ten or so follicles grow each month and of these, only one goes on to deliver an egg bursting to release its ripened egg into the fallopian tube.
However, around one woman in every hundred runs out eggs before her 40th birthday, triggering early menopause, so she is no longer able to have children naturally.
Today, in the journal Science, Dr Kui Liu of Umeå University, Sweden, Prof Ilpo Huhtaniemi of Imperial College London and colleagues in China and America report that the enzyme PTEN keeps immature eggs from ripening prematurely. "It is a kind of brake," says Prof Huhtaniemi.
The team finds that in mice lacking PTEN in their eggs, the entire pool of immature eggs is activated prematurely, becoming ripe so the mouse uses up it store of eggs more rapidly..
Prof Huhtaniemi says that PTEN works in humans too and that the team is now going to investigate whether mutations in the PTEN gene are linked with premature menopause in women. "We have one good candidate to explain why some women develop premature menopause," he says.
A drug to mimic the effects of PTEN could be used to prevent or treat premature menopause when combined with new tests that can show how quickly a woman's biological clock is ticking. By the same token, a way to block the effects of PTEN could lead to new ways to ripen eggs for IVF, notably if eggs fail to ripen in the first place, says Dr Liu.
To overcome how women only make one egg each month and obtain more for IVF treatments, or to create embryos if they are to undergo fertility threatening cancer treatments, doctors have used expensive hormones to stimulate them to ripen multiple eggs, which does carry some risks.
But some women seeking to preserve their child-bearing capacity may not have enough time to undergo ovarian stimulation or may have a condition that makes it dangerous, such as hormone-sensitive breast cancer.
Lab-dish or "in vitro" egg maturation has produced hundreds of babies worldwide, though is still experimental.
Now PTEN offers another way to ripen eggs, says Dr Liu. "With the knowledge that PTEN suppresses follicle activation, it is in theory possible to culture a piece of the ovaries in the petri-dish and trigger the follicle growth with a synthetic PTEN inhibitor, which we have started to try".
Such a method will enrich the source of eggs for IVF or who want to freeze their embryos before going to have chemotherapy or radiation therapy for cancer, says Dr Liu.
Source: http://www.telegraph.co.uk/earth/main.jhtml?view=DETAILS&grid=&xml=/earth/2008/01/31/scimeno131.xml
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As fertility-treatment costs soar -- and more women seek treatment at an older age -- a growing number of Americans are heading abroad to try to get pregnant.The Internet has made it easier for women to connect with fertility clinics in diverse locales such as the Czech Republic, Israel, Canada and Thailand. And specialized travel services have sprung up to help people arrange accommodations, set up medical appointments and even plan sightseeing tours.
The cost of in-vitro fertilization in many foreign countries is a fraction of that in the U.S., even after factoring in expenses for travel and accommodations. And some women say they have been able to get treatment abroad after having been turned away by a U.S. clinic because of their age.
There are some downsides. Treatments can take four or five weeks -- too long for many couples to take a break from their regular lives. It might not be possible to find medical practitioners who speak fluent English, though some of the travel firms also provide translation services. And while medical standards are high in many countries, regulations can vary, including rules for screening egg donors, leaving it to patients to do due diligence. In the U.S., the Food and Drug Administration regulates egg-donor screening, though some states set stricter standards.
"Money was a factor" for Robyn Bova, 47 years old, in deciding with her husband to travel to the Clinic of Reproductive Medicine and Gynecology in Zlin, a college town in the Czech Republic, for IVF treatment in May and again in November after their first attempt failed. Though initially concerned about everything from the health of the egg donors to the medical standards, Ms. Bova researched the clinic and contacted other American women who'd gone there. "I thought, if we get there and it's horrible, we don't have to go through with it," she says.
Ms. Bova says she was pleased with the treatment she received and is now 17 weeks pregnant. And during their time in Eastern Europe, "we had the most incredible trips you could imagine." Ms. Bova says the total price tag for both trips, including travel, hotels, food and treatments, was $22,000, or roughly the cost of one round of in-vitro fertilization in the U.S.
The Bovas booked their overseas treatment through IVFVacation.com, which was started by Craig and Marcela Fite. The Ohio couple had traveled to Marcela's native Czech Republic for their own IVF treatments and decided to serve as middlemen for Americans wishing to do the same. The couple charge between $1,500 and $2,500 for their services, which include arranging appointments at the clinic and providing on-site assistance for driving and translations.
Other such service providers include IVFThailand.com, a Web site that helps arrange treatments at a fertility clinic in Thailand. And the CHEN Patient Fertility Association, an Israeli fertility group that promotes fertility treatments along with sightseeing tours around the Holy Land.
"We're just now starting to see foreign clinics market themselves to U.S. patients," says Barbara Collura, executive director of Resolve: The National Infertility Association.
U.S. fertility doctors say that while IVF isn't a high-risk medical procedure, patients going abroad should consider several things, including the reputation and number of procedures performed, and the success and complication rates of a clinic -- information the clinic should be able to provide. Also worth considering: liability and patients' rights to take legal action if something goes wrong. "There are great and good hospitals in many countries," says Zev Rosenwaks, director of the Center for Reproductive Medicine and Infertility at New York Weill Cornell Center. "One has to look at the overall medical standards and I think it's much harder to judge from far away."While Americans have increasingly gone abroad in recent years for medical procedures ranging from hip replacements to face lifts, fertility treatments have largely remained an outlier. Concerns about medical standards and the strong emotions that often surround infertility have persuaded many people seeking IVF treatment to stick close to home.
But outsize costs and relatively sparse insurance coverage at home are driving more Americans to seek treatments abroad. The cost of fertility treatments in the U.S. varies by region and depends on the procedures needed. A single round of IVF with a woman's own eggs, including medications, costs on average about $12,000, according to Resolve, but can run much higher. For IVF using donor eggs, the cost can add as much as $5,000 to $15,000. Prices have risen steadily in recent years as more-advanced technology and additional options have emerged.
The in-vitro fertilization process involves stimulating a woman's ovaries with hormone treatments, extracting eggs for fertilization, and then implanting embryos in her uterus. Alternatively, a donor's eggs are used to create an embryo. Insurance plans sometimes cover aspects of the process, such as the drug treatments, or they might cover a single round. Only a handful of states, including Massachusetts, require some form of IVF coverage.
It can be difficult to compare success rates of women getting pregnant from IVF treatments because of the different ways statistics are collected. In the U.S., the rate of live single births from IVF transfer was 40.5% in women under 35, according to the Centers for Disease Control and Prevention 2005 Assisted Reproductive Technology Report. That fell to 13.1% in women ages 41 to 42. In Europe, 18.6% of IVF transfers resulted in pregnancies, according to 2003 statistics from the European Society of Human Reproduction and Embryology, which doesn't break out data by age.
Age restrictions for fertility treatments vary in the U.S. by clinic and by the individual health of the patients. For women using their own eggs, the age cutoff is usually early 40s; if using donor eggs, it's usually late 40s to 50.
Full article: http://online.wsj.com/article/SB120338119629575619.html?mod=hpp_us_personal_journal
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Background: It is not known whether infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have a higher risk of birth defects than infants conceived naturally.
Methods: We obtained data from three registries in Western Australia on births, births after assisted conception, and major birth defects in infants born between 1993 and 1997. We assessed the prevalence of major birth defects diagnosed by one year of age in infants conceived naturally or with use of intracytoplasmic sperm injection or in vitro fertilization.
Results: Twenty-six of the 301 infants conceived with intracytoplasmic sperm injection (8.6 percent) and 75 of the 837 infants conceived with in vitro fertilization (9.0 percent) had a major birth defect diagnosed by one year of age, as compared with 168 of the 4000 naturally conceived infants (4.2 percent; P greater than 0.001 for the comparison between either type of technology and natural conception).
As compared with natural conception, the odds ratio for a major birth defect by one year of age, after adjustment for maternal age and parity, the sex of the infant, and correlation between siblings, was 2.0 (95 percent confidence interval, 1.3 to 3.2) with intracytoplasmic sperm injection, and 2.0 (95 percent confidence interval, 1.5 to 2.9) with in vitro fertilization. Infants conceived with use of assisted reproductive technology were more likely than naturally conceived infants to have multiple major defects and to have chromosomal and musculoskeletal defects.
Conclusions: Infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have twice as high a risk of a major birth defect as naturally conceived infants.
New England Journal of Medicine: Volume 346:725-730, March 7, 2002, Number 10
Full article: https://content.nejm.org/cgi/content/full/346/10/725?ck=nck
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Methods: We obtained data from three registries in Western Australia on births, births after assisted conception, and major birth defects in infants born between 1993 and 1997. We assessed the prevalence of major birth defects diagnosed by one year of age in infants conceived naturally or with use of intracytoplasmic sperm injection or in vitro fertilization.
Results: Twenty-six of the 301 infants conceived with intracytoplasmic sperm injection (8.6 percent) and 75 of the 837 infants conceived with in vitro fertilization (9.0 percent) had a major birth defect diagnosed by one year of age, as compared with 168 of the 4000 naturally conceived infants (4.2 percent; P greater than 0.001 for the comparison between either type of technology and natural conception).
As compared with natural conception, the odds ratio for a major birth defect by one year of age, after adjustment for maternal age and parity, the sex of the infant, and correlation between siblings, was 2.0 (95 percent confidence interval, 1.3 to 3.2) with intracytoplasmic sperm injection, and 2.0 (95 percent confidence interval, 1.5 to 2.9) with in vitro fertilization. Infants conceived with use of assisted reproductive technology were more likely than naturally conceived infants to have multiple major defects and to have chromosomal and musculoskeletal defects.
Conclusions: Infants conceived with use of intracytoplasmic sperm injection or in vitro fertilization have twice as high a risk of a major birth defect as naturally conceived infants.
New England Journal of Medicine: Volume 346:725-730, March 7, 2002, Number 10
Full article: https://content.nejm.org/cgi/content/full/346/10/725?ck=nck
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Studies find fertilization inhibited by compound that resembles cannabis
In a finding that could send shivers down the spines of pot-smoking couples hoping to conceive, new research is raising the possibility that marijuana could interfere with reproduction.
New studies show that a cannabis-like compound inhibits the ability of human sperm to fertilize an egg. Also, high concentrations of THC -- the psychoactive ingredient in marijuana -- appear to cause structural changes in sperm as they become ready and able to reach and fuse with a woman's egg.
While pot smoking may not yet qualify as a contraceptive, the findings presented yesterday at the American Society for Cell Biology meeting at Moscone Center in San Francisco are some of the first indications that marijuana use could reduce fertility in both men and women.
Previous research has shown a link between heavy pot smoking and low sperm counts. The latest study focuses on a substance called anandamide that is produced by the body and which acts very much like THC on a cellular level.
It is one of a class of substances called cannabinoids that bind to receptors on cells that also respond to THC. Cannabinoids are found throughout the body and their affect on various systems is only now being studied.
In a series of experiments, researchers at the University of Buffalo-SUNY found that a synthetic form of anandamide reduced by half the number of sperm that were able to attach to a human egg. Furthermore, high concentrations of anandamide slowed down sperm's swimming ability, while low levels kicked it into overdrive.
The researchers also bathed human sperm in solutions containing either THC or anandamide and found that both substances significantly altered the normal structural changes sperm go through as they prepare to approach and bind with an egg.
FREQUENT USE MAY CAUSE TROUBLE
"For people who are very heavy marijuana users, there may be reproductive consequences associated with that," said Herbert Schuel, a professor of anatomy and cell biology at the University of Buffalo and lead author of the study.
More generally, Schuel said, it is possible that glitches in the normal anandamide system could be linked to some cases of unexplained infertility.
Gregory Kopf, a professor in the obstetrics and gynecology department at the University of Pennsylvania, said he was intrigued by the findings, but added that he was not sure that the concentrations of anandamide used in the experiments would ever be reached in the reproductive tracts of people who smoke pot.
Kopf's research focuses on the signals between cells that occur when an egg is fertilized and begins to divide into an embryo.
Although there have been anecdotal reports of marijuana's adverse effect on fetal development and fertility, there have been virtually no formal studies to show whether or not a link exists, said S.K. Dey of the University of Kansas Medical Center.
A COMPOUND'S COMPLEX EFFECTS
Dey has shown that, in mice, excessive amounts of anandamide or an unusually large number of receptors for it on an embryo increases the risk that the fetus will miscarry. Furthermore, he said, in a normal mouse pregnancy, the number of the receptors and the level of anandamide both go down just before the embryo is implanted.
Dey has followed Schuel's research and said he is one of the few scientists focusing on cannabinoids and their effects on the human body outside of the brain.
"People have gotten so focused on the brain function (of anandamide and related compounds) and very little focus has been on its effect on early pregnancy," he said.
Schuel said the federal government's restrictive stance on marijuana- related research has hindered the field. But he said it is attracting more interest as scientists learn more about how cannabinoids affect everything from circulation to digestion to cancer.
Source: http://www.mindfully.org/Health/Marijuana-Hurt-Conception.htm
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Studies find fertilization inhibited by compound that resembles cannabis
In a finding that could send shivers down the spines of pot-smoking couples hoping to conceive, new research is raising the possibility that marijuana could interfere with reproduction.
New studies show that a cannabis-like compound inhibits the ability of human sperm to fertilize an egg. Also, high concentrations of THC -- the psychoactive ingredient in marijuana -- appear to cause structural changes in sperm as they become ready and able to reach and fuse with a woman's egg.
While pot smoking may not yet qualify as a contraceptive, the findings presented yesterday at the American Society for Cell Biology meeting at Moscone Center in San Francisco are some of the first indications that marijuana use could reduce fertility in both men and women.
Previous research has shown a link between heavy pot smoking and low sperm counts. The latest study focuses on a substance called anandamide that is produced by the body and which acts very much like THC on a cellular level.
It is one of a class of substances called cannabinoids that bind to receptors on cells that also respond to THC. Cannabinoids are found throughout the body and their affect on various systems is only now being studied.
In a series of experiments, researchers at the University of Buffalo-SUNY found that a synthetic form of anandamide reduced by half the number of sperm that were able to attach to a human egg. Furthermore, high concentrations of anandamide slowed down sperm's swimming ability, while low levels kicked it into overdrive.
The researchers also bathed human sperm in solutions containing either THC or anandamide and found that both substances significantly altered the normal structural changes sperm go through as they prepare to approach and bind with an egg.
FREQUENT USE MAY CAUSE TROUBLE
"For people who are very heavy marijuana users, there may be reproductive consequences associated with that," said Herbert Schuel, a professor of anatomy and cell biology at the University of Buffalo and lead author of the study.
More generally, Schuel said, it is possible that glitches in the normal anandamide system could be linked to some cases of unexplained infertility.
Gregory Kopf, a professor in the obstetrics and gynecology department at the University of Pennsylvania, said he was intrigued by the findings, but added that he was not sure that the concentrations of anandamide used in the experiments would ever be reached in the reproductive tracts of people who smoke pot.
Kopf's research focuses on the signals between cells that occur when an egg is fertilized and begins to divide into an embryo.
Although there have been anecdotal reports of marijuana's adverse effect on fetal development and fertility, there have been virtually no formal studies to show whether or not a link exists, said S.K. Dey of the University of Kansas Medical Center.
A COMPOUND'S COMPLEX EFFECTS
Dey has shown that, in mice, excessive amounts of anandamide or an unusually large number of receptors for it on an embryo increases the risk that the fetus will miscarry. Furthermore, he said, in a normal mouse pregnancy, the number of the receptors and the level of anandamide both go down just before the embryo is implanted.
Dey has followed Schuel's research and said he is one of the few scientists focusing on cannabinoids and their effects on the human body outside of the brain.
"People have gotten so focused on the brain function (of anandamide and related compounds) and very little focus has been on its effect on early pregnancy," he said.
Schuel said the federal government's restrictive stance on marijuana- related research has hindered the field. But he said it is attracting more interest as scientists learn more about how cannabinoids affect everything from circulation to digestion to cancer.
Source: http://www.mindfully.org/Health/Marijuana-Hurt-Conception.htm
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AT least six British mothers have frozen their eggs so their infertile daughters can use them to give birth to their half brothers or sisters.
The women want to give their daughters, who have medical conditions which prevent them from producing eggs of their own, the chance to become mothers.
The mother-to-daughter egg donation has been made possible by advances in freezing technology that enable eggs to be stored long enough for the child to use them.
Once the daughters reach adulthood, conventional in vitro fertilization (IVF) can then be used to allow their husbands to inseminate the eggs before implantation.
Some doctors say mothers should now be encouraged to freeze their eggs for their daughters’ use as soon as the offspring are diagnosed with conditions such as Turner syndrome, where sufferers lack ovaries.
The mothers only have a short period in which they can make the donation to their daughters because, by the time they reach the age of 40, their eggs are likely to be of too poor quality to store.
Dr Gillian Lockwood, medical director of Midland Fertility Services, where one mother has already frozen her eggs for her daughter and another is preparing to do the same, said: “The perfect egg donors for girls with Turner syndrome are their own mothers.”
The plans for women to give birth to their half siblings have, however, been criticised by some ethicists who fear that it could cause the daughters psychological problems, while the resulting children could be confused about their relationship to their mother and grandmother.
Josephine Quintavalle of Comment on Reproductive Ethics said: “The child could feel a crisis of identity trying to work out their relationship with relatives. The daughter’s husband may also feel an obligation to fertilise his mother-in-law’s eggs.” But fertility doctors say many women would prefer to have a child with a genetic link.
Professor Gedis Grudzinskas, a consultant gynaecologist at the Bridge Centre, in London, where one mother is preparing to store eggs for her daughter’s use, added: “This is a right and proper way to use this egg-freezing technology. It is a natural urge for women to want to become grandparents.”
Five women, whose daughters suffer from Turner syndrome or a metabolic condition, have frozen their eggs at Care Fertility, a chain of clinics across the Midlands and the north of England.
Source: http://www.timesonline.co.uk/tol/news/uk/science/article3341852.ece
TODAY'S BOOK SUGGESTION:
It Starts with the Egg:
How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF
by Rebecca Fett
-- Whether you are trying to conceive naturally or through IVF, the quality of your eggs will have a powerful impact on how long it takes you to get pregnant and whether you face an increased risk of miscarriage.
Poor egg quality is emerging as the single most important cause of age-related infertility, recurrent miscarriage, and failed IVF cycles. It is also a major contributor to infertility in PCOS.
Based on a comprehensive investigation of a vast array of scientific research, It Starts with the Egg reveals a groundbreaking new approach for improving egg quality and fertility.
With a concrete strategy including minimizing exposure to toxins such as BPA and phthalates, choosing the right vitamins and supplements to safeguard developing eggs, and harnessing nutritional advice shown to boost IVF success rates, this book offers practical solutions to will help you get pregnant faster and deliver a healthy baby.
Paperback: 304 pages
Click to order/for more info: It Starts with the Egg
Start reading It Starts with the Egg on your Kindle in under a minute!
Don't have a Kindle? Get your Kindle here, or download a FREE Kindle Reading App.
The women want to give their daughters, who have medical conditions which prevent them from producing eggs of their own, the chance to become mothers.
The mother-to-daughter egg donation has been made possible by advances in freezing technology that enable eggs to be stored long enough for the child to use them.
Once the daughters reach adulthood, conventional in vitro fertilization (IVF) can then be used to allow their husbands to inseminate the eggs before implantation.
Some doctors say mothers should now be encouraged to freeze their eggs for their daughters’ use as soon as the offspring are diagnosed with conditions such as Turner syndrome, where sufferers lack ovaries.
The mothers only have a short period in which they can make the donation to their daughters because, by the time they reach the age of 40, their eggs are likely to be of too poor quality to store.
Dr Gillian Lockwood, medical director of Midland Fertility Services, where one mother has already frozen her eggs for her daughter and another is preparing to do the same, said: “The perfect egg donors for girls with Turner syndrome are their own mothers.”
The plans for women to give birth to their half siblings have, however, been criticised by some ethicists who fear that it could cause the daughters psychological problems, while the resulting children could be confused about their relationship to their mother and grandmother.
Josephine Quintavalle of Comment on Reproductive Ethics said: “The child could feel a crisis of identity trying to work out their relationship with relatives. The daughter’s husband may also feel an obligation to fertilise his mother-in-law’s eggs.” But fertility doctors say many women would prefer to have a child with a genetic link.
Professor Gedis Grudzinskas, a consultant gynaecologist at the Bridge Centre, in London, where one mother is preparing to store eggs for her daughter’s use, added: “This is a right and proper way to use this egg-freezing technology. It is a natural urge for women to want to become grandparents.”
Five women, whose daughters suffer from Turner syndrome or a metabolic condition, have frozen their eggs at Care Fertility, a chain of clinics across the Midlands and the north of England.
Source: http://www.timesonline.co.uk/tol/news/uk/science/article3341852.ece
TODAY'S BOOK SUGGESTION:
It Starts with the Egg:How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF
by Rebecca Fett
-- Whether you are trying to conceive naturally or through IVF, the quality of your eggs will have a powerful impact on how long it takes you to get pregnant and whether you face an increased risk of miscarriage.
Poor egg quality is emerging as the single most important cause of age-related infertility, recurrent miscarriage, and failed IVF cycles. It is also a major contributor to infertility in PCOS.
Based on a comprehensive investigation of a vast array of scientific research, It Starts with the Egg reveals a groundbreaking new approach for improving egg quality and fertility.
With a concrete strategy including minimizing exposure to toxins such as BPA and phthalates, choosing the right vitamins and supplements to safeguard developing eggs, and harnessing nutritional advice shown to boost IVF success rates, this book offers practical solutions to will help you get pregnant faster and deliver a healthy baby.
Paperback: 304 pagesClick to order/for more info: It Starts with the Egg
Start reading It Starts with the Egg on your Kindle in under a minute!Don't have a Kindle? Get your Kindle here, or download a FREE Kindle Reading App.
You can't stop a woman's biological clock. But now, researchers can stop her eggs from aging, which makes having a biological child a reality for women in their forties and fifties. Researchers are also trying to make pregnancy possible for women without a uterus.
By her mid thirties, Adrienne Domasin knew she wanted a baby, even though she was single. "I didn't really feel like I had to meet someone, so I said, I can do this thing, so I went ahead with it," Domasin says.
At age 36, she turned to fertility specialist Jane Frederick for help. "It's not necessarily that infertility is becoming worse, it's that women are waiting to have a baby at an older age," says Jane Frederick, M.D., an infertility specialist at Extend Fertility in Laguna Hills, Calif.
Ignoring her biological clock could cost a woman her chance at motherhood. Egg quality peaks at age 27, declines rapidly through her thirties and by 42, a woman has little chance at getting pregnant with her own eggs.
"It's not how important the age of the woman is, but it's the age of her egg that determines success," Dr. Frederick says.
Now, science lets women freeze their eggs. "When the egg is frozen, it's in an ageless state and it stays frozen until you thaw it and fertilize it in the test tube and create an embryo," Dr. Frederick says.
Doctors have been freezing embryos -- eggs fertilized with sperm -- for more than twenty years. But freezing eggs before they're fertilized is a challenge. Eggs, which are mostly water, form damaging ice crystals during the freezing process. "And then the egg doesn't survive when you thaw it," Dr. Frederick says.
But a recent breakthrough in the cryoprotectant used in egg-freezing has made it possible. Still, a single thawed egg results in pregnancy less than 4-percent of the time, compared to 43-percent with fresh eggs. So far, only about 600 babies have been born from frozen eggs.
"This technology is giving women a lot more tools to actually be able to control their reproductive lifespan," Dr. Frederick says.
Domasin had 11 eggs frozen. She came back four months later to have six fertilized. Now, she has Noah. "It was like a real emotional month for a while, when I really realized the gravity of what I had done ... by myself," Domasin says.
What makes Domasin's story even more unique -- Noah is the nation's first baby born from a frozen egg and frozen sperm. "I just want him to have a normal life," Domasin says.
But in the fertility world, normal is hard to define. Transplant surgeon Andreas Tzakis wants to be the first in the world to transplant a human uterus, giving women who have had hysterectomies a chance to give birth. His research is currently in pigs.
"We have five animals that are quite healthy with transplanted uteri and they are waiting to be pregnant," says Andreas Tzakis, M.D., Ph.D., transplant surgeon at the Diabetes Research Institute in Miami, Fla.
Like other transplanted organs, having a donor womb would require taking anti-rejection drugs. But unlike a liver or a heart, a uterus can simply be removed after giving birth. "I can only imagine the impact that it will have," Dr. Tzakis says.
Dr. Tzakis says women have already called wanting to be part of future human trials. "I think it will be within the next few years," Dr. Tzakis says.
It costs as much as $600 a year to store frozen eggs at a clinic until they're ready to be fertilized. Dr. Frederick says a woman can carry a pregnancy well into her forties, fifties and possibly sixties.
FOR MORE INFORMATION, PLEASE CONTACT:
Egg-Freezing:
Extend Fertility
329 Washington St., Suite 200
Woburn, MA 01801
(800) 841-7197
For an Extend Fertility office near you, log onto:
www.extendfertility.com
Uterine Transplants:
Omar Montejo
University of Miami Public Relations
1600 NW 10th Ave.
RMSB 1149
Miami, FL 33136
(305) 243-5654
omontejo@med.miami.edu
Source: http://www.news4jax.com/health/15253564/detail.html
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By her mid thirties, Adrienne Domasin knew she wanted a baby, even though she was single. "I didn't really feel like I had to meet someone, so I said, I can do this thing, so I went ahead with it," Domasin says.
At age 36, she turned to fertility specialist Jane Frederick for help. "It's not necessarily that infertility is becoming worse, it's that women are waiting to have a baby at an older age," says Jane Frederick, M.D., an infertility specialist at Extend Fertility in Laguna Hills, Calif.
Ignoring her biological clock could cost a woman her chance at motherhood. Egg quality peaks at age 27, declines rapidly through her thirties and by 42, a woman has little chance at getting pregnant with her own eggs.
"It's not how important the age of the woman is, but it's the age of her egg that determines success," Dr. Frederick says.
Now, science lets women freeze their eggs. "When the egg is frozen, it's in an ageless state and it stays frozen until you thaw it and fertilize it in the test tube and create an embryo," Dr. Frederick says.
Doctors have been freezing embryos -- eggs fertilized with sperm -- for more than twenty years. But freezing eggs before they're fertilized is a challenge. Eggs, which are mostly water, form damaging ice crystals during the freezing process. "And then the egg doesn't survive when you thaw it," Dr. Frederick says.
But a recent breakthrough in the cryoprotectant used in egg-freezing has made it possible. Still, a single thawed egg results in pregnancy less than 4-percent of the time, compared to 43-percent with fresh eggs. So far, only about 600 babies have been born from frozen eggs.
"This technology is giving women a lot more tools to actually be able to control their reproductive lifespan," Dr. Frederick says.
Domasin had 11 eggs frozen. She came back four months later to have six fertilized. Now, she has Noah. "It was like a real emotional month for a while, when I really realized the gravity of what I had done ... by myself," Domasin says.
What makes Domasin's story even more unique -- Noah is the nation's first baby born from a frozen egg and frozen sperm. "I just want him to have a normal life," Domasin says.
But in the fertility world, normal is hard to define. Transplant surgeon Andreas Tzakis wants to be the first in the world to transplant a human uterus, giving women who have had hysterectomies a chance to give birth. His research is currently in pigs.
"We have five animals that are quite healthy with transplanted uteri and they are waiting to be pregnant," says Andreas Tzakis, M.D., Ph.D., transplant surgeon at the Diabetes Research Institute in Miami, Fla.
Like other transplanted organs, having a donor womb would require taking anti-rejection drugs. But unlike a liver or a heart, a uterus can simply be removed after giving birth. "I can only imagine the impact that it will have," Dr. Tzakis says.
Dr. Tzakis says women have already called wanting to be part of future human trials. "I think it will be within the next few years," Dr. Tzakis says.
It costs as much as $600 a year to store frozen eggs at a clinic until they're ready to be fertilized. Dr. Frederick says a woman can carry a pregnancy well into her forties, fifties and possibly sixties.
FOR MORE INFORMATION, PLEASE CONTACT:
Egg-Freezing:
Extend Fertility
329 Washington St., Suite 200
Woburn, MA 01801
(800) 841-7197
For an Extend Fertility office near you, log onto:
www.extendfertility.com
Uterine Transplants:
Omar Montejo
University of Miami Public Relations
1600 NW 10th Ave.
RMSB 1149
Miami, FL 33136
(305) 243-5654
omontejo@med.miami.edu
Source: http://www.news4jax.com/health/15253564/detail.html
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Acupuncture appears to be a useful fertility aid, according to a new report in the British Medical Journal that found pairing acupuncture with in-vitro fertilization can raise a couple's odds of getting pregnant by 65 percent.
In absolute terms, the report found that for every 10 women who supplement IVF with acupuncture, one extra pregnancy will occur.
Although that's a "modest" effect, it's important given the emotions and considerable expenses associated with assisted reproduction, said Eric Manheimer, the lead author and a research associate at the University of Maryland Medical School.
The new report -- a synthesis of seven previously published studies involving 1,366 patients -- doesn't address why acupuncture promotes fertility, which patients benefit or what protocol is optimal.
But experts have several ideas. They suggest that the ancient Chinese practice -- which involves inserting needles at strategic locations on a person's body -- might enhance blood flow to the uterus, improving the chance that an embryo will successfully implant. Also, it's thought that acupuncture might stimulate the production of hormones that regulate ovulation and fertility and regulate stress, which can interfere with a pregnancy.
Some fertility centers have responded with enthusiasm. "We offer acupuncture to all our IVF patients" and between 10 and 20 percent elect to use it, said Dr. Brian Kaplan, a fertility specialist at Fertility Centers of Illinois.
Kaplan cautioned, however, that he couldn't recommend acupuncture as a stand-alone fertility treatment, without IVF.
Other scientists are skeptical. Dr. Norbert Gleicher, president of the Center for Human Reproduction, said he didn't find the scientific literature convincing.
Gleicher's fertility centers will arrange for acupuncture occasionally, when patients indicate they want it, he said.
"None of the studies, including this new one, are definitive," agreed Dr. Ralph Kazer, chief of reproductive endocrinology at Northwestern University's Feinberg School of Medicine.
Two years ago, Northwestern launched a study of up to 220 women in which half get "sham" acupuncture, with needles placed in the wrong locations, and half get the real thing.
The goal is to determine whether the placement of needles makes a difference or whether the therapy works because women believe it does, Kazer said.
Summing it up
The study: A review of existing research has found that acupuncture can boost a woman's odds of conceiving.
The caveats: The results apply only when acupuncture is used with in-vitro fertilization. And not all experts are convinced that it helps.
Local angle: Fertility centers across Chicago are touting acupuncture as a way to help women get pregnant.
Drawbacks? There are no harmful effects associated with acupuncture, which calls for needles to be inserted across a woman's body.
Source: http://www.chicagotribune.com/features/lifestyle/health/chi-acupuncture_08feb08,1,7564638.story?ctrack=1&cset=true
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In absolute terms, the report found that for every 10 women who supplement IVF with acupuncture, one extra pregnancy will occur.
Although that's a "modest" effect, it's important given the emotions and considerable expenses associated with assisted reproduction, said Eric Manheimer, the lead author and a research associate at the University of Maryland Medical School.
The new report -- a synthesis of seven previously published studies involving 1,366 patients -- doesn't address why acupuncture promotes fertility, which patients benefit or what protocol is optimal.
But experts have several ideas. They suggest that the ancient Chinese practice -- which involves inserting needles at strategic locations on a person's body -- might enhance blood flow to the uterus, improving the chance that an embryo will successfully implant. Also, it's thought that acupuncture might stimulate the production of hormones that regulate ovulation and fertility and regulate stress, which can interfere with a pregnancy.
Some fertility centers have responded with enthusiasm. "We offer acupuncture to all our IVF patients" and between 10 and 20 percent elect to use it, said Dr. Brian Kaplan, a fertility specialist at Fertility Centers of Illinois.
Kaplan cautioned, however, that he couldn't recommend acupuncture as a stand-alone fertility treatment, without IVF.
Other scientists are skeptical. Dr. Norbert Gleicher, president of the Center for Human Reproduction, said he didn't find the scientific literature convincing.
Gleicher's fertility centers will arrange for acupuncture occasionally, when patients indicate they want it, he said.
"None of the studies, including this new one, are definitive," agreed Dr. Ralph Kazer, chief of reproductive endocrinology at Northwestern University's Feinberg School of Medicine.
Two years ago, Northwestern launched a study of up to 220 women in which half get "sham" acupuncture, with needles placed in the wrong locations, and half get the real thing.
The goal is to determine whether the placement of needles makes a difference or whether the therapy works because women believe it does, Kazer said.
Summing it up
The study: A review of existing research has found that acupuncture can boost a woman's odds of conceiving.
The caveats: The results apply only when acupuncture is used with in-vitro fertilization. And not all experts are convinced that it helps.
Local angle: Fertility centers across Chicago are touting acupuncture as a way to help women get pregnant.
Drawbacks? There are no harmful effects associated with acupuncture, which calls for needles to be inserted across a woman's body.
Source: http://www.chicagotribune.com/features/lifestyle/health/chi-acupuncture_08feb08,1,7564638.story?ctrack=1&cset=true
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JAYNE knows first-hand the joys and trials of being an older mother. She conceived her only child, Cara, now nearly eight, naturally at the age of 43, after meeting her partner later in life.
"It was a massive adjustment," Jayne said. But she said she wouldn't change a thing, and described Cara as "a real blessing".
The Herald Sun's revelation yesterday that a Victorian woman was set to become the state's oldest first-time mother was a hot topic on talkback radio and around water coolers.
The woman will be 54 when she gives birth this year, after trying to conceive for more than two decades.
Medical ethicist Nicholas Tonti-Filippini said the IVF team who helped the woman conceive were irresponsible and had not fulfilled their legal obligations to act in the best interest of the baby.
"It is not in the best interest of the child to have a mother who has a seriously increased risk of a difficult pregnancy and an increased risk of having a disabled child," Dr Tonti-Filippini said.
"Also, it is not ideal to have such a huge generation gap between the child and the mother. When this child is 21, she will be 75."
The number of Victorian women aged 40-49 giving birth almost doubled in the past decade, jumping from 1349 in 1996 to 2579 in 2006, according to the Australian Bureau of Statistics. The number aged 45-49 more than doubled, from 55 in 1996, to 113 in 2006.
Older mum Jayne said she thought delayed motherhood was becoming the norm because women wanted to establish themselves in a career first.
"Also, it is a matter of finding the right partner -- that seems to becoming harder and harder," she said.
Jayne, 51, said she had almost accepted that she would remain single and childless when she met her partner in her 40s.
She became pregnant after trying for six months, and had a textbook pregnancy and birth. However, life with a newborn baby proved to be a big change.
"I think younger women probably have more energy to handle it," she said.
Father Kevin McGovern, director of the Caroline Chisholm Centre for Health Ethics, said he did not have a problem with a mother's age.
"With regards as to whether someone is too old to be a mum at 54, I really can't comment without knowing the folk involved," Father McGovern said.
But he said he had a problem with the use of fertility treatment in general.
"Our greatest concern is the commodification of the child, that the child ends up being a commodity rather than being a gift from God."
Source: http://www.news.com.au/heraldsun/story/0,21985,23177589-2862,00.html
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"It was a massive adjustment," Jayne said. But she said she wouldn't change a thing, and described Cara as "a real blessing".
The Herald Sun's revelation yesterday that a Victorian woman was set to become the state's oldest first-time mother was a hot topic on talkback radio and around water coolers.
The woman will be 54 when she gives birth this year, after trying to conceive for more than two decades.
Medical ethicist Nicholas Tonti-Filippini said the IVF team who helped the woman conceive were irresponsible and had not fulfilled their legal obligations to act in the best interest of the baby.
"It is not in the best interest of the child to have a mother who has a seriously increased risk of a difficult pregnancy and an increased risk of having a disabled child," Dr Tonti-Filippini said.
"Also, it is not ideal to have such a huge generation gap between the child and the mother. When this child is 21, she will be 75."
The number of Victorian women aged 40-49 giving birth almost doubled in the past decade, jumping from 1349 in 1996 to 2579 in 2006, according to the Australian Bureau of Statistics. The number aged 45-49 more than doubled, from 55 in 1996, to 113 in 2006.
Older mum Jayne said she thought delayed motherhood was becoming the norm because women wanted to establish themselves in a career first.
"Also, it is a matter of finding the right partner -- that seems to becoming harder and harder," she said.
Jayne, 51, said she had almost accepted that she would remain single and childless when she met her partner in her 40s.
She became pregnant after trying for six months, and had a textbook pregnancy and birth. However, life with a newborn baby proved to be a big change.
"I think younger women probably have more energy to handle it," she said.
Father Kevin McGovern, director of the Caroline Chisholm Centre for Health Ethics, said he did not have a problem with a mother's age.
"With regards as to whether someone is too old to be a mum at 54, I really can't comment without knowing the folk involved," Father McGovern said.
But he said he had a problem with the use of fertility treatment in general.
"Our greatest concern is the commodification of the child, that the child ends up being a commodity rather than being a gift from God."
Source: http://www.news.com.au/heraldsun/story/0,21985,23177589-2862,00.html
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As many women postpone having a baby until later in their lives, some will face infertility. But infertility is treatable through a variety of therapies, says Howard A. Zacur, director of Johns Hopkins Medicine's Division of Reproductive Endocrinology and Infertility.
How many women are affected by fertility problems?
Roughly 10 percent of women in the United States who are trying to become pregnant are affected, and this percentage has been relatively stable over time.
Medically speaking, how is infertility defined?
The common definition is the inability to become pregnant after trying for 12 months. But this is a very imprecise definition because it is known that a certain percentage of women who aren't pregnant after 12 months will become pregnant eventually if they keep trying.
But there is the "biological clock" factor, if you will, to consider. If you have an individual at age 39 or 40 who has not become pregnant after trying for 12 months, you certainly would want to act on the assumption that she is infertile -- because if you wait longer, she may have a depletion of her eggs, so fertility may be compromised further.
What are some of the causes of infertility?
When I talk to patients about this, I say, "OK, in order to become pregnant, you have to have eggs in the ovaries. You have to release them or ovulate. You have to have a partner or a source of sperm. And the passageway from the vagina to the cervix and fallopian tubes must be open in order to allow sperm and egg to meet. So any problem along those lines will result in infertility.
For example, if there is a low egg reserve in the ovaries or if the eggs are not released and so on, this will result in infertility. Those are the standard causes of infertility.
Are there other causes?
Yes. Some other causes might include endometriosis, which is when the lining of the uterine cavity is found to be growing elsewhere in the body such as on the surface of the ovary or uterus. How endometriosis causes infertility remains unknown. We and other medical centers continue to study how best to diagnose and treat this disease. Just because you have endometriosis does not mean that you are infertile, but if your fallopian tubes are both blocked, then you will have infertility.
When should a woman or couple consult a doctor about infertility?
As a general rule, couples should consider seeking medical help if they have been unable to conceive after one year of trying to become pregnant. Also, if the woman is 38 years of age or older, an evaluation for infertility might begin after less than a year of trying simply because there is a decline in the number of eggs in the ovaries with each passing year.
Could you describe some of the available therapies?
The types of therapy include stimulating the ovary with an oral medication called clompihene citrate. This affects the brain, pituitary gland and ovaries and doesn't result in a high percentage of multiple births.
Another therapy includes the patient taking clompihene citrate with intrauterine insemination -- or artificial insemination. In this therapy, a semen sample is taken and processed so that the sperm is suspended in a known buffer and is injected into the uterus.
And there is in vitro fertilization [or IVF]. Simply put, this is when you stimulate the ovary to get more than one egg and then surgically remove the eggs with a simple procedure. Then you mix them with sperm from the partner and fertilization takes place. This results in embryos, and one or two or three of the embryos can be put back in the uterus.
It's important for women to remember that the chances of becoming pregnant through this therapy are much better before 40 than after 40 years of age.
What's new in the area of infertility?
Assisted reproductive technologies, such as in vitro fertilization, are improving and are being used more frequently to treat infertility -- even before such procedures as a laparoscopy [a procedure in which a tiny video camera is inserted through a tube into the body] are done.
Women who are older and who have decreased numbers of eggs remaining in their ovaries are now able to benefit from IVF.
And patients may benefit from a more personalized treatment plan, which takes into consideration their age, medical histories and other factors.
This is a more targeted approach to diagnosing and treating a patient's infertility issues than the traditional fixed-protocol approaches.
When a patient first seeks treatment with you, what do you typically tell them?
Infertility is something that we can treat and do a very good job of treating. What I say to patients is that it really is perseverance that matters.
If you have this problem and continue with treatment -- then chances of success are high. It is very hard not to become frustrated and give up.
What about cost?
Maryland is one of the few states that has mandated, if you will, insurance for IVF, but there are strings on that. And I think there is an effort to restrict that. I hope that doesn't happen because it is a very effective therapy, and it could mean avoidance of a surgical procedure. But it is an expensive treatment to be sure.
Source: http://www.baltimoresun.com/entertainment/custom/today/bal-to.hs.expert31jan31,0,5129430.story
Life Begins...
Miscarriage stories of loss, hope & help
http://born2luv.blogspot.com/
Stories of Pregnancy & Birth over 44y
- Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
4,400 Stories of Pregnancy & Birth over 44y
Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
Recent Keyword Searches: can you get pregnant at 43, can you get pregnant at 47, books women in perimenopause getting pregnant using do, is it possible to get prenant at age 48, is there a drug i can take to help me get pregnate i am 47, the truth about pregnancy at 40, how to get pregnant in late 40s, how to get pregnant when you are over 50 in uk, what are the chances of getting pregnant at age 50 naturally, help for older women wanting to get pregnant
How many women are affected by fertility problems?
Roughly 10 percent of women in the United States who are trying to become pregnant are affected, and this percentage has been relatively stable over time.
Medically speaking, how is infertility defined?
The common definition is the inability to become pregnant after trying for 12 months. But this is a very imprecise definition because it is known that a certain percentage of women who aren't pregnant after 12 months will become pregnant eventually if they keep trying.
But there is the "biological clock" factor, if you will, to consider. If you have an individual at age 39 or 40 who has not become pregnant after trying for 12 months, you certainly would want to act on the assumption that she is infertile -- because if you wait longer, she may have a depletion of her eggs, so fertility may be compromised further.
What are some of the causes of infertility?
When I talk to patients about this, I say, "OK, in order to become pregnant, you have to have eggs in the ovaries. You have to release them or ovulate. You have to have a partner or a source of sperm. And the passageway from the vagina to the cervix and fallopian tubes must be open in order to allow sperm and egg to meet. So any problem along those lines will result in infertility.
For example, if there is a low egg reserve in the ovaries or if the eggs are not released and so on, this will result in infertility. Those are the standard causes of infertility.
Are there other causes?
Yes. Some other causes might include endometriosis, which is when the lining of the uterine cavity is found to be growing elsewhere in the body such as on the surface of the ovary or uterus. How endometriosis causes infertility remains unknown. We and other medical centers continue to study how best to diagnose and treat this disease. Just because you have endometriosis does not mean that you are infertile, but if your fallopian tubes are both blocked, then you will have infertility.
When should a woman or couple consult a doctor about infertility?
As a general rule, couples should consider seeking medical help if they have been unable to conceive after one year of trying to become pregnant. Also, if the woman is 38 years of age or older, an evaluation for infertility might begin after less than a year of trying simply because there is a decline in the number of eggs in the ovaries with each passing year.
Could you describe some of the available therapies?
The types of therapy include stimulating the ovary with an oral medication called clompihene citrate. This affects the brain, pituitary gland and ovaries and doesn't result in a high percentage of multiple births.
Another therapy includes the patient taking clompihene citrate with intrauterine insemination -- or artificial insemination. In this therapy, a semen sample is taken and processed so that the sperm is suspended in a known buffer and is injected into the uterus.
And there is in vitro fertilization [or IVF]. Simply put, this is when you stimulate the ovary to get more than one egg and then surgically remove the eggs with a simple procedure. Then you mix them with sperm from the partner and fertilization takes place. This results in embryos, and one or two or three of the embryos can be put back in the uterus.
It's important for women to remember that the chances of becoming pregnant through this therapy are much better before 40 than after 40 years of age.
What's new in the area of infertility?
Assisted reproductive technologies, such as in vitro fertilization, are improving and are being used more frequently to treat infertility -- even before such procedures as a laparoscopy [a procedure in which a tiny video camera is inserted through a tube into the body] are done.
Women who are older and who have decreased numbers of eggs remaining in their ovaries are now able to benefit from IVF.
And patients may benefit from a more personalized treatment plan, which takes into consideration their age, medical histories and other factors.
This is a more targeted approach to diagnosing and treating a patient's infertility issues than the traditional fixed-protocol approaches.
When a patient first seeks treatment with you, what do you typically tell them?
Infertility is something that we can treat and do a very good job of treating. What I say to patients is that it really is perseverance that matters.
If you have this problem and continue with treatment -- then chances of success are high. It is very hard not to become frustrated and give up.
What about cost?
Maryland is one of the few states that has mandated, if you will, insurance for IVF, but there are strings on that. And I think there is an effort to restrict that. I hope that doesn't happen because it is a very effective therapy, and it could mean avoidance of a surgical procedure. But it is an expensive treatment to be sure.
Source: http://www.baltimoresun.com/entertainment/custom/today/bal-to.hs.expert31jan31,0,5129430.story
Life Begins...
Miscarriage stories of loss, hope & help
http://born2luv.blogspot.com/
Stories of Pregnancy & Birth over 44y
- Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
4,400 Stories of Pregnancy & Birth over 44y
Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
Recent Keyword Searches: can you get pregnant at 43, can you get pregnant at 47, books women in perimenopause getting pregnant using do, is it possible to get prenant at age 48, is there a drug i can take to help me get pregnate i am 47, the truth about pregnancy at 40, how to get pregnant in late 40s, how to get pregnant when you are over 50 in uk, what are the chances of getting pregnant at age 50 naturally, help for older women wanting to get pregnant
The stress, money and marital problems were bad enough. But after months of trying and failing to get pregnant, the ultimate blow came when a good friend didn't invite Paula Dowd to a baby shower for fear it would be hurtful.
"People can't relate," Dowd said. "They don't understand what you're going through. You start to feel more and more socially isolated."
Dowd's struggle with infertility, which she eventually overcame, led to a new outlook on life - and a major career change. A few years after her ordeal began, Dowd quit her job as a marketing director, went back to school and become a counselor to help infertile women.
This month, Dowd will begin support classes at her new MindBodyWellness clinic in Redondo Beach, a practice that she hopes will complement fertility physicians in the South Bay.
"As a society, we tend to minimize the impact that infertility has on women," Dowd said. "For some women, particularly in some minority cultures, child-bearing is their sole purpose in life. It's like, if I can't do this, who am I?"
More women than ever are struggling with fertility problems. Roughly 15 percent of couples - whether the problem be with the woman, man or both - can't conceive for a variety of reasons, according to the Centers for Disease Control.
Health experts say one of the factors is that women are waiting longer to have children. The number of new mothers over 40 tripled from 1980 to 2005, according to the California Public Policy Institute. Nationally, the average age of first-time mothers rose to an all-time high of 27 in 2005. After the age of 35, it becomes much more difficult for women to conceive naturally.
Dowd was certainly in tune with today's trend. At 32, she and her husband decided they were emotionally and financially ready for a family. After a year of failed attempts, she started to get worried.
They spent thousands of dollars on various medical procedures, but nothing worked. She was also diagnosed with polycystic ovary syndrome, a condition in which the female body produces a high level of androgens, or male hormones, that inhibit pregnancy.
Tensions were running high, she said. Dowd had no problem adopting, but as an only child, she wanted at least one biological child.
"I had a strong desire to carry that genetic link to the future," she said.
She decided to try a 10-week mind-body class suggested by her fertility doctor. In the group meetings, participants talked about what they were going through, meditated, practiced yoga and learned how to take care of themselves.
Armed with a calming CD of music, she went to her doctor for in vitro fertilization, an expensive procedure in which the eggs and sperm are fertilized in a petri dish. A month later, at age 34, she was pregnant.
"It was totally different that time," she said. "I went into it completely relaxed, centered."
Research shows that when stressed, the body triggers the "flight or fight" response and releases toxins to ward off danger. Those toxins can lead to a number of health problems, including infertility, she said.
Dowd was resigned to adopt a second child - she and her husband had already spent about $30,000 on fertility treatments, which weren't covered by insurance. But she continued to practice her relaxation techniques, and became pregnant again at 37 without any medical assistance.
That's when Dowd became a believer. After being approached by a few women at work who struggled with similar problems, the new mother decided on a new career path.
She became a licensed counselor and began working with women individually at a MindBodyWellness clinic in Santa Monica. Dowd, who is now 40, plans to hold her first group meeting at her new offices on Palos Verdes Boulevard later this month.
In addition to helping women conceive, she said she hopes her work will create happier women, and therefore happier mothers. Even if women can't conceive, "they will become parents if they want to be," she said, referring to adoption and other options.
"We don't realize how much control we have over our bodies," she said. "For me this is about giving women possibility and hope."
FIND OUT MORE
For information about the MindBodyWellness clinic in Redondo Beach, call 310-373-9355 or go to http://www.mindbodywellnessla.com/ .
Source: http://www.dailybreeze.com/ci_8170715
Life Begins...
Miscarriage stories of loss, hope & help
http://born2luv.blogspot.com/
Stories of Pregnancy & Birth over 44y
- Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
4,400 Stories of Pregnancy & Birth over 44y
Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
Recent Keyword Searches: trying to get pregnant in your forties, chances she's pregnant 45 yr old woman, can a pre-menopause woman get pregnant?, percentage of miscarriage in woman over 40, perimenopausal or pregnant at 42, how many women get pregnant at 44, how to get pregnant late in life, how to get pregnant at 43, can you get pregnant during the menopause, getting pregnant late 40s
"People can't relate," Dowd said. "They don't understand what you're going through. You start to feel more and more socially isolated."
Dowd's struggle with infertility, which she eventually overcame, led to a new outlook on life - and a major career change. A few years after her ordeal began, Dowd quit her job as a marketing director, went back to school and become a counselor to help infertile women.
This month, Dowd will begin support classes at her new MindBodyWellness clinic in Redondo Beach, a practice that she hopes will complement fertility physicians in the South Bay.
"As a society, we tend to minimize the impact that infertility has on women," Dowd said. "For some women, particularly in some minority cultures, child-bearing is their sole purpose in life. It's like, if I can't do this, who am I?"
More women than ever are struggling with fertility problems. Roughly 15 percent of couples - whether the problem be with the woman, man or both - can't conceive for a variety of reasons, according to the Centers for Disease Control.
Health experts say one of the factors is that women are waiting longer to have children. The number of new mothers over 40 tripled from 1980 to 2005, according to the California Public Policy Institute. Nationally, the average age of first-time mothers rose to an all-time high of 27 in 2005. After the age of 35, it becomes much more difficult for women to conceive naturally.
Dowd was certainly in tune with today's trend. At 32, she and her husband decided they were emotionally and financially ready for a family. After a year of failed attempts, she started to get worried.
They spent thousands of dollars on various medical procedures, but nothing worked. She was also diagnosed with polycystic ovary syndrome, a condition in which the female body produces a high level of androgens, or male hormones, that inhibit pregnancy.
Tensions were running high, she said. Dowd had no problem adopting, but as an only child, she wanted at least one biological child.
"I had a strong desire to carry that genetic link to the future," she said.
She decided to try a 10-week mind-body class suggested by her fertility doctor. In the group meetings, participants talked about what they were going through, meditated, practiced yoga and learned how to take care of themselves.
Armed with a calming CD of music, she went to her doctor for in vitro fertilization, an expensive procedure in which the eggs and sperm are fertilized in a petri dish. A month later, at age 34, she was pregnant.
"It was totally different that time," she said. "I went into it completely relaxed, centered."
Research shows that when stressed, the body triggers the "flight or fight" response and releases toxins to ward off danger. Those toxins can lead to a number of health problems, including infertility, she said.
Dowd was resigned to adopt a second child - she and her husband had already spent about $30,000 on fertility treatments, which weren't covered by insurance. But she continued to practice her relaxation techniques, and became pregnant again at 37 without any medical assistance.
That's when Dowd became a believer. After being approached by a few women at work who struggled with similar problems, the new mother decided on a new career path.
She became a licensed counselor and began working with women individually at a MindBodyWellness clinic in Santa Monica. Dowd, who is now 40, plans to hold her first group meeting at her new offices on Palos Verdes Boulevard later this month.
In addition to helping women conceive, she said she hopes her work will create happier women, and therefore happier mothers. Even if women can't conceive, "they will become parents if they want to be," she said, referring to adoption and other options.
"We don't realize how much control we have over our bodies," she said. "For me this is about giving women possibility and hope."
FIND OUT MORE
For information about the MindBodyWellness clinic in Redondo Beach, call 310-373-9355 or go to http://www.mindbodywellnessla.com/ .
Source: http://www.dailybreeze.com/ci_8170715
Life Begins...
Miscarriage stories of loss, hope & help
http://born2luv.blogspot.com/
Stories of Pregnancy & Birth over 44y
- Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
4,400 Stories of Pregnancy & Birth over 44y
Daily blog of hope & inspiration!
http://pregnancyover44y.blogspot.com/
Recent Keyword Searches: trying to get pregnant in your forties, chances she's pregnant 45 yr old woman, can a pre-menopause woman get pregnant?, percentage of miscarriage in woman over 40, perimenopausal or pregnant at 42, how many women get pregnant at 44, how to get pregnant late in life, how to get pregnant at 43, can you get pregnant during the menopause, getting pregnant late 40s
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